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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Capsid protein: Evidences about the partial protective role of neutralizing antibody-independent immunity against dengue in monkeys
Virology, Volume 456-457, No. 1, Year 2014
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Description
The role of cellular immune response in dengue virus infection is not yet fully understood. Only few studies in murine models propose that CD8+ T-cells are associated with protection from infection and disease. At the light of recent reports about the protective role of CD8+ T-cells in humans and the no correlation between neutralizing antibodies and protection observed in several studies, a vaccine based on cell-mediated immunity constitute an attractive approach. Our group has developed a capsid-based vaccine as nucleocpasid-like particles from dengue-2 virus, which induced a protective CD4+ and CD8+ cell-mediated immunity in mice, without the contribution of neutralizing antibodies. Herein we evaluated the immunogenicity and protective efficacy of this molecule in monkeys. Neither IgG antibodies against the whole virus nor neutralizing antibodies were elicited after the antigen inoculation. However, animals developed a cell-mediated immunity, measured by gamma interferon secretion and cytotoxic capacity. Although only one out of three vaccinated animals was fully protected against viral challenge, a viral load reduction was observed in this group compared with the placebo one, suggesting that capsid could be the base on an attractive vaccine against dengue. © 2014 Elsevier Inc.
Authors & Co-Authors
Gil, Lázaro
Cuba, Havana
Center for Genetic Engineering and Biotechnology Havana
Izquierdo, Alienys
Cuba
Instituto de Medicina Tropical Pedro Kouri
Lazo, Laura
Cuba, Havana
Center for Genetic Engineering and Biotechnology Havana
Valdés, Iris
Cuba, Havana
Center for Genetic Engineering and Biotechnology Havana
Ambala, Peris
Kenya, Nairobi
National Museums of Kenya
Ochola, Lucy B.
Kenya, Nairobi
National Museums of Kenya
Marcos, Ernesto
Cuba, Havana
Center for Genetic Engineering and Biotechnology Havana
Suzarte, Edith
Cuba, Havana
Center for Genetic Engineering and Biotechnology Havana
Kariuki, Thomas M.
Kenya, Nairobi
National Museums of Kenya
Guzmán, Guadalupe
Cuba
Instituto de Medicina Tropical Pedro Kouri
Guillen, Gerardo
Cuba, Havana
Center for Genetic Engineering and Biotechnology Havana
Hermida, Lisset
Cuba, Havana
Center for Genetic Engineering and Biotechnology Havana
Statistics
Citations: 27
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1016/j.virol.2014.03.011
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Infectious Diseases