Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Effects of human TRIM5α polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection
Virology, Volume 354, No. 1, Year 2006
Notification
URL copied to clipboard!
Description
TRIM5α acts on several retroviruses, including human immunodeficiency virus (HIV-1), to restrict cross-species transmission. Using natural history cohorts and tissue culture systems, we examined the effect of polymorphism in human TRIM5α on HIV-1 infection. In African Americans, the frequencies of two non-coding SNP variant alleles in exon 1 and intron 1 of TRIM5 were elevated in HIV-1-infected persons compared with uninfected subjects. By contrast, the frequency of the variant allele encoding TRIM5α 136Q was relatively elevated in uninfected individuals, suggesting a possible protective effect. TRIM5α 136Q protein exhibited slightly better anti-HIV-1 activity in tissue culture than the TRIM5α R136 protein. The 43Y variant of TRIM5α was less efficient than the H43 variant at restricting HIV-1 and murine leukemia virus infections in cultured cells. The ancestral TRIM5 haplotype specifying no observed variant alleles appeared to be protective against infection, and the corresponding wild-type protein partially restricted HIV-1 replication in vitro. A single logistic regression model with a permutation test indicated the global corrected P value of < 0.05 for both SNPs and haplotypes. Thus, polymorphism in human TRIM5 may influence susceptibility to HIV-1 infection, a possibility that merits additional evaluation in independent cohorts. © 2006 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Javanbakht, Hassan
United States, Boston
Harvard Medical School
An, Ping
United States, Frederick
Saic-frederick
Gold, Bert
United States, Frederick
National Cancer Institute at Frederick
Petersen, Desiree C.
South Africa, Stellenbosch
Stellenbosch University
O'Huigín, Colm S.
United States, Frederick
Saic-frederick
Nelson, George W.
United States, Frederick
Saic-frederick
O'Brien, Stephen J.
United States, Frederick
National Cancer Institute at Frederick
Kirk, Gregory D.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Detels, Roger R.
United States, Los Angeles
Ucla Fielding School of Public Health
Buchbinder, Susan P.
United States, San Francisco
University of California, San Francisco
Donfield, Sharyne M.
United States, Chapel Hill
Rho, Inc.
Shulenin, Sergey
United States, Frederick
National Cancer Institute at Frederick
Song, Byeongwoon
United States, Boston
Harvard Medical School
Perron, Michel J.
United States, Boston
Harvard Medical School
Stremlau, Matthew H.
United States, Boston
Harvard Medical School
Sodroski, Joseph G.
United States, Boston
Harvard Medical School
United States, Boston
Harvard T.h. Chan School of Public Health
Dean, Michael C.
United States, Frederick
National Cancer Institute at Frederick
Winkler, Cheryl Ann
United States, Frederick
Saic-frederick
Statistics
Citations: 113
Authors: 18
Affiliations: 9
Identifiers
Doi:
10.1016/j.virol.2006.06.031
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study