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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Neocosmospora sp.-derived resorcylic acid lactones with in vitro binding affinity for human opioid and cannabinoid receptors
Journal of Natural Products, Volume 76, No. 5, Year 2013
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Description
Bioassay-guided fractionation of a fungus Neocosmospora sp. (UM-031509) resulted in the isolation of three new resorcylic acid lactones, neocosmosin A (2), neocosmosin B (3), and neocosmosin C (4). Three known resorcylic acid lactones, monocillin IV (1), monocillin II (5), and radicicol (6), were also isolated and identified. The structures of these compounds were established on the basis of extensive 1D and 2D NMR spectroscopic analysis, mass spectrometric (ESIMS) data, and X-ray crystallography. Compounds 4-6 show good binding affinity for the human opioid receptors. These findings have important implications for evaluating the potential psychoactive effects with this class of compounds. © 2013 The American Chemical Society and American Society of Pharmacognosy.
Authors & Co-Authors
Gao, Jiangtao
United States, Oxford
University of Mississippi
Radwan, Mohamed M.
United States, Oxford
University of Mississippi
León, Francisco
United States, Oxford
University of Mississippi
Dale, Olivia Reed
United States, Oxford
University of Mississippi
Husni, Afeef S.
United States, Oxford
University of Mississippi
Wu, Yunshan
United States, Oxford
University of Mississippi
Lupien, Shari L.
United States, Washington, D.c.
United States Department of Agriculture
Wang, Xiaoning
United States, Oxford
University of Mississippi
Manly, Susan P.
United States, Oxford
University of Mississippi
Hill, Robert A.
New Zealand, Lincoln
Lincoln University
Dugan, Frank M.
United States, Washington, D.c.
United States Department of Agriculture
Cutler, Horace G.
United States, Atlanta
Mercer University at Atlanta
Cutler, Stephen J.
United States, Oxford
University of Mississippi
Statistics
Citations: 33
Authors: 13
Affiliations: 4
Identifiers
Doi:
10.1021/np300653d
ISSN:
01633864
Research Areas
Substance Abuse