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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Transmission of HIV-1 drug resistance in Switzerland: A 10-year molecular epidemiology survey
AIDS, Volume 21, No. 16, Year 2007
Notification
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Description
OBJECTIVES: Representative prevalence data of transmitted drug-resistant HIV-1 are essential to establish accurate guidelines addressing resistance testing and first-line treatments. METHODS: Systematic resistance testing was carried out in individuals in Switzerland with documented HIV-1 seroconversion during 1996-2005 and available samples with RNA > 1000 copies/ml obtained within 1 year of estimated seroconversion. Resistance interpretation used the Stanford list of mutations for surveillance of transmitted drug resistance and the French National Agency for AIDS Research algorithm. RESULTS: Viral sequences from 822 individuals were available. Risk groups were men having sex with men (42%), heterosexual contacts (32%) and intravenous drug users (20%); 30% were infected with non-B subtype viruses. Overall, prevalence of transmitted resistance was 7.7% [95% confidence interval (CI), 5.9-9.5] for any drug, 5.5% (95% CI, 3.9-7.1) for nucleoside reverse transcriptase inhibitors, 1.9% (95% CI, 1.0-2.8) for non-nucleoside reverse transcriptase inhibitors and 2.7% (95% CI, 1.6-3.8) for protease inhibitors. Dual- or triple-class resistance was observed in 2% (95% CI, 0.8-2.5). No significant trend in prevalence of transmitted resistance was observed over years. There were no differences according to ethnicity, risk groups or gender, but prevalence of transmitted resistance was highest among individuals infected with subtype B virus. CONCLUSIONS: The transmission rate of drug-resistant HIV-1 has been stable since 1996, with very rare transmission of dual- or triple-class resistance. These data suggest that transmission of drug resistance in the setting of easy access to antiretroviral treatment can remain stable and be kept at a low level. © 2007 Lippincott Williams & Wilkins, Inc.
Authors & Co-Authors
Yerly, Sabine T.B.D.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
von Wyl, Viktor
Switzerland, Zurich
Universitatsspital Zurich
Ledergerber, Bruno
Switzerland, Zurich
Universitatsspital Zurich
Böni, Jürg
Switzerland, Zurich
Universitatsspital Zurich
Schüpbach, Jörg
Switzerland, Zurich
Universität Zürich
Bürgisser, Ph
Ghana, Accra
Central University
Klimkait, Thomas
Switzerland, Basel
University of Basel, Institute for Medical Microbiology
Rickenbach, Martin
Switzerland, Lausanne
Swiss Hiv Cohort Study Data Center
Kaiser, Laurent K.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Günthard, Huldrych F.
Switzerland, Zurich
Universitatsspital Zurich
Perrin, Luc Henri
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Battegay, Manuel
Unknown Affiliation
Bernasconi, Enos
Unknown Affiliation
Böni, Jürg
Unknown Affiliation
Bucher, Heiner C.
Unknown Affiliation
Bürgisser, Ph
Unknown Affiliation
Cattacin, Sandro
Unknown Affiliation
Cavassini, Matthias L.
Unknown Affiliation
Dubs, Rolf W.
Unknown Affiliation
Egger, Matthias
Unknown Affiliation
Elzi, Luigia
Unknown Affiliation
Erb, Peter
Unknown Affiliation
Fischer, Marek
Unknown Affiliation
Flepp, Markus J.
Unknown Affiliation
Fontana, Adriano
Unknown Affiliation
Francioli, Patrick B.
Unknown Affiliation
Furrer, Hansjakob
Unknown Affiliation
Gorgievski, Meri
Unknown Affiliation
Günthard, Hüldrych Fritz
Unknown Affiliation
Hirsch, Hans H.
Unknown Affiliation
Hirschel, Bernard J.
Unknown Affiliation
Hösli, Irene Mathilde
Unknown Affiliation
Kahlert, Christian R.
Unknown Affiliation
Kaiser, L.
Unknown Affiliation
Karrer, Urs
Unknown Affiliation
Kind, Christian H.
Unknown Affiliation
Martinetti, Gladys
Unknown Affiliation
Martinez, Begogna
Unknown Affiliation
Müller, Nicolas J.
Unknown Affiliation
Nadal, David
Unknown Affiliation
Opravil, Milos
Unknown Affiliation
Paccaud, Fred Michel
Unknown Affiliation
Pantaleo, Giuseppe P.
Unknown Affiliation
Rudin, Christoph
Unknown Affiliation
Schmid, Patrick
Unknown Affiliation
Schültze, Detlev
Unknown Affiliation
Speck, Roberto F.
Unknown Affiliation
Taffé, Patrick
Unknown Affiliation
Tarr, Philip E.
Unknown Affiliation
Telenti, Amalio
Unknown Affiliation
Trkola, Alexandra
Unknown Affiliation
Vernazza, Pietro Luigi
Unknown Affiliation
Weber, Rainer
Unknown Affiliation
Statistics
Citations: 149
Authors: 53
Affiliations: 6
Identifiers
Doi:
10.1097/QAD.0b013e3282f0b685
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Participants Gender
Male