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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Co-morbidity of epilepsy in Tanzanian children: A community-based case-control study
Seizure, Volume 21, No. 3, Year 2012
Notification
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Description
Purpose: To define the prevalence and associations of co-morbidity and school attendance in older children with epilepsy (CWE) from a rural district of Tanzania by conducting a community-based case-control study. Methods: Children aged 6-14 years old with active epilepsy (at least two unprovoked seizures in the last five years) were identified in a cross-sectional survey in Tanzania. Co-morbidities were assessed and cases were compared with age-matched controls. Results: Co-morbidity was very common amongst cases (95/112, 85%), with 62/112 (55%) having multiple co-morbidities. Co-morbidities consisted of cognitive impairment (72/112, 64%), behaviour disorder 68/112 (61%), motor difficulties 29/112 (26%), burns and other previous injuries (29/112, 26%). These complications were significantly more common in cases than in controls (odds ratio 14.8, 95%CI 7.6-28.6, p < 0.001). Co-morbidity in CWE was associated with structural cause, abnormal electroencephalogram and early onset seizures. Cognitive impairment was very common in CWE (64%) and was not associated with Phenobarbital use but was associated with motor difficulties, early onset and recurrent seizures. Poor school attendance was found in 56/112 (50%) of CWE, but not in the controls: it was associated with the presence of multiple co-morbidities, especially with motor difficulties in CWE. Conclusion: Children with epilepsy in a rural area of sub-Saharan Africa had a high level of co-morbidity. Cognitive impairment and poor school attendance were very common. These associated difficulties in CWE in the region need to be addressed to reduce the negative impact of epilepsy on these children. Crown Copyright © 2011 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3672980/bin/mmc1.pdf
Authors & Co-Authors
Burton, K.
Unknown Affiliation
Rogathe, Jane J.
Unknown Affiliation
Whittaker, Roger Graham
Unknown Affiliation
Mankad, Kshitij
Unknown Affiliation
Hunter, Ewan
Unknown Affiliation
Burton, Matthew J.
Unknown Affiliation
Todd, Jim E.
Unknown Affiliation
Neville, Brian G.R.
Unknown Affiliation
Walker, Richard William
Unknown Affiliation
Newton, Charles R.J.C.
Unknown Affiliation
Statistics
Citations: 26
Authors: 10
Affiliations: 10
Identifiers
Doi:
10.1016/j.seizure.2011.10.011
ISSN:
10591311
e-ISSN:
15322688
Research Areas
Maternal And Child Health
Violence And Injury
Study Design
Cross Sectional Study
Case-Control Study
Study Approach
Quantitative
Study Locations
Tanzania