Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Morbidity and mortality due to shigella and enterotoxigenic Escherichia coli diarrhoea: the Global Burden of Disease Study 1990–2016
The Lancet Infectious Diseases, Volume 18, No. 11, Year 2018
Notification
URL copied to clipboard!
Description
Background: Shigella and enterotoxigenic Escherichia coli (ETEC) are bacterial pathogens that are frequently associated with diarrhoeal disease, and are a significant cause of mortality and morbidity worldwide. The Global Burden of Diseases, Injuries, and Risk Factors study 2016 (GBD 2016) is a systematic, scientific effort to quantify the morbidity and mortality due to over 300 causes of death and disability. We aimed to analyse the global burden of shigella and ETEC diarrhoea according to age, sex, geography, and year from 1990 to 2016. Methods: We modelled shigella and ETEC-related mortality using a Bayesian hierarchical modelling platform that evaluates a wide range of covariates and model types on the basis of vital registration and verbal autopsy data. We used a compartmental meta-regression tool to model the incidence of shigella and ETEC, which enforces an association between incidence, prevalence, and remission on the basis of scientific literature, population representative surveys, and health-care data. We calculated 95% uncertainty intervals (UIs) for the point estimates. Findings: Shigella was the second leading cause of diarrhoeal mortality in 2016 among all ages, accounting for 212 438 deaths (95% UI 136 979–326 913) and about 13·2% (9·2–17·4) of all diarrhoea deaths. Shigella was responsible for 63 713 deaths (41 191–93 611) among children younger than 5 years and was frequently associated with diarrhoea across all adult age groups, increasing in elderly people, with broad geographical distribution. ETEC was the eighth leading cause of diarrhoea mortality in 2016 among all age groups, accounting for 51 186 deaths (26 757–83 064) and about 3·2% (1·8–4·7) of diarrhoea deaths. ETEC was responsible for about 4·2% (2·2–6·8) of diarrhoea deaths in children younger than 5 years. Interpretation: The health burden of bacterial diarrhoeal pathogens is difficult to estimate. Despite existing prevention and treatment options, they remain a major cause of morbidity and mortality globally. Additional emphasis by public health officials is needed on a reduction in disease due to shigella and ETEC to reduce disease burden. Funding: Bill & Melinda Gates Foundation. © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Authors & Co-Authors
Troeger, Christopher E.
United States, Seattle
Institute for Health Metrics and Evaluation
Blacker, Brigette F.
United States, Seattle
Institute for Health Metrics and Evaluation
Rao, Puja C.
United States, Seattle
Institute for Health Metrics and Evaluation
Brown, Alexandria
United States, Seattle
Institute for Health Metrics and Evaluation
Atherly, Deborah E.
United States, Seattle
Path Seattle
Brewer, Thomas G.
United States, Seattle
University of Washington
Engmann, Cyril Mark
United States, Seattle
Path Seattle
United States, Seattle
University of Washington
United States, Seattle
University of Washington School of Medicine
Houpt, Eric R.
United States, Charlottesville
University of Virginia
Kang, Gagandeep
India, Faridabad
Translational Health Science and Technology Institute
Kotloff, Karen L.
United States, Baltimore
University of Maryland School of Medicine
Levin, Myron J.
United States, Baltimore
University of Maryland School of Medicine
Luby, Stephen P.
United States, Palo Alto
Stanford University
MacLennan, Calman Alexander
Unknown Affiliation
Pan, William K.Y.
United States, Seattle
Institute for Health Metrics and Evaluation
United States, Durham
Duke University
Pavlinac, Patricia B.
United States, Seattle
University of Washington
Platts-Mills, James A.
United States, Charlottesville
University of Virginia
Qadri, Firdausi
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Riddle, Mark S.
United States, Bethesda
Uniformed Services University of the Health Sciences
Ryan, Edward Thomas
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
United States, Boston
Harvard T.h. Chan School of Public Health
Steele, Andrew Duncan
Unknown Affiliation
Walson, Judd L.
United States, Seattle
University of Washington
United States, Seattle
University of Washington School of Medicine
Sanders, John Walton
United States, Winston Salem
Wake Forest University School of Medicine
Mokdad, Ali H.I.
United States, Seattle
Institute for Health Metrics and Evaluation
Murray, Christopher J.L.
United States, Seattle
Institute for Health Metrics and Evaluation
Hay, Simon I.
United States, Seattle
Institute for Health Metrics and Evaluation
United Kingdom, Oxford
University of Oxford
Reiner, Robert Charles
United States, Seattle
Institute for Health Metrics and Evaluation
Statistics
Citations: 346
Authors: 26
Affiliations: 17
Identifiers
Doi:
10.1016/S1473-3099(18)30475-4
ISSN:
14733099
Research Areas
Disability
Health System And Policy
Infectious Diseases
Maternal And Child Health
Violence And Injury
Study Design
Cross Sectional Study
Cohort Study