Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A systematic review of rotavirus strain diversity in India, Bangladesh, and Pakistan
Vaccine, Volume 30, No. SUPPL. 1, Year 2012
Notification
URL copied to clipboard!
Description
Of the estimated half-million deaths from rotavirus globally each year, approximately one-third (N= 160,000 deaths) occur in the Indian subcontinent (defined as India, Bangladesh, and Pakistan). Two commercial vaccines are available for use and recommended by WHO, although the prohibitive vaccine price has limited their introduction into routine childhood immunization programs. New rotavirus vaccines are in late clinical development, including two advanced candidates in India. As significant shifts in rotavirus strain diversity have occurred in the past three decades and questions remain regarding whether strain replacement may occur following introduction of rotavirus vaccines, it is important to understand the temporal and regional strain diversity profile before vaccine introduction. We reviewed 33 peer-reviewed manuscripts from the Indian subcontinent and found that the most common G-types (G1-4) and P-types (P[4] and P[8]) globally accounted for three-fourths of all strains in the subcontinent. However, strains varied by region, and temporal analysis showed the decline of G3 and G4 in recent years and the emergence of G9 and G12. Our findings underscore the large diversity of rotavirus strains in the Indian subcontinent and highlight the need to conduct surveillance on a regional scale to better understand strain diversity before and after rotavirus vaccine introduction. © 2012.
Authors & Co-Authors
Miles, Melody G.
United States, Seattle
Path Seattle
Lewis, Kristen D.C.
United States, Seattle
Path Seattle
Kang, Gagandeep
India, Vellore
Christian Medical College, Vellore
Parashar, Umesh D.
United States, Atlanta
Centers for Disease Control and Prevention
Steele, Andrew Duncan
United States, Seattle
Path Seattle
Statistics
Citations: 55
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.vaccine.2011.10.002
ISSN:
18732518
Research Areas
Maternal And Child Health
Study Approach
Systematic review