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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Occult HBV infection in Morocco: From chronic hepatitis to hepatocellular carcinoma
Liver International, Volume 34, No. 6, Year 2014
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Description
Background & Aims: Morocco is one of low to intermediate endemic areas for hepatitis B virus (HBV) infection, but no reports have been published on Occult HBV infection (OBI). To determine the prevalence of OBI and its clinical impact among patients with cryptogenic and HCV-related chronic liver disease in Morocco. Methods: A total of 152 HBsAg-negative patients (60 patients with cryptogenic hepatitis and 92 HCV carriers) were enrolled in this study. Sera collected from all patients were tested for anti-HBc and anti-HBs antibodies. OBI was assessed in serum and liver tissue samples using highly sensitive PCR assays targeting Surface, X and core regions of the HBV genome and confirmed by Southern blot hybridization. Results: A high rate of anti-HBc positivity was found among patients with HCV infection (57/92, 61.95%) compared to those with cryptogenic hepatitis (24/60, 40%) (P = 0.034). A high prevalence of OBI was found among patients with HCV infection (42/92, 45.65%) compared to those with cryptogenic hepatitis (17/60, 28.3%) (P = 0.013). In both groups, the prevalence of OBI increased in parallel with advancing stage of liver disease (χ2 = 6.73; P = 0.0095). The highest proportion of OBI was reached among HCV-related HCC cases (62.5%). Multivariate Cox regression analysis revealed that older age (≥56 years), positivity for anti-HBc and presence of OBI were independent risk factors for the development of HCC in HCV-infected patients. Conclusion: This study helps to understand the current status of OBI and its impact on the severity of liver disease in Moroccan patients. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Authors & Co-Authors
Kitab, Bouchra
Morocco, Casablanca
Institut Pasteur du Maroc
Ezzikouri, Sayeh
Morocco, Casablanca
Institut Pasteur du Maroc
Alaoui, Rhimou
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Nadir, Salwa
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Badre, Wafaa
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Trépo, Christian R.
France, Lyon
Centre de Recherche en Cancérologie de Lyon
Chemin, Isabelle A.
France, Lyon
Centre de Recherche en Cancérologie de Lyon
Benjelloun, Soumaya
Morocco, Casablanca
Institut Pasteur du Maroc
Statistics
Citations: 24
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1111/liv.12482
ISSN:
14783223
e-ISSN:
14783231
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Morocco