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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Characterization of the rabbit agouti signaling protein (ASIP) gene: Transcripts and phylogenetic analyses and identification of the causative mutation of the nonagouti black coat colour
Genomics, Volume 95, No. 3, Year 2010
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Description
The agouti locus encodes the agouti signalling protein (ASIP) which is involved in determining the switch from eumelanin to pheomelanin synthesis in melanocytes. In the domestic rabbit (Oryctolagus cuniculus) early studies indicated three alleles at this locus: A, light-bellied agouti (wild type); at, black and tan; a, black nonagouti. We characterized the rabbit ASIP gene and identified the causative mutation (an insertion in exon 2) of the black nonagouti allele whose frequency was evaluated in 31 breeds. Phylogenetic analysis of ASIP sequences from Oryctolagus and 9 other species of the family Leporidae placed Oryctolagus as sister species to Pentalagus and Bunolagus. Transcription analysis in wild type agouti rabbits revealed the presence of two major transcripts with different 5′-untranslated regions having ventral or dorsal skin specific expression. ASIP gene transcripts were also detected in all examined rabbit tissues distinguishing the rabbit expression pattern from what was observed in wild type mice. © 2009 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Fontanesi, Luca
Italy, Bologna
Alma Mater Studiorum Università Di Bologna
Forestier, Lionel
France, Limoges
Université de Limoges
Allain, Daniel
France, Castanet-tolosan
Inrae Occitanie-toulouse Centre
Scotti, Emilio
Italy, Bologna
Alma Mater Studiorum Università Di Bologna
Beretti, Francesca
Italy, Bologna
Alma Mater Studiorum Università Di Bologna
Deretz-Picoulet, Séverine
France, Lusignan
Centre Inrae Nouvelle-aquitaine Poitiers
Pecchioli, Elena
Italy, San Michele All'adige
Fondazione Edmund Mach
Vernesi, Cristiano
Italy, San Michele All'adige
Fondazione Edmund Mach
Robinson, Terence J.
South Africa, Stellenbosch
Stellenbosch University
Malaney, Jason L.
United States, Albuquerque
The University of new Mexico
Russo, Vincenzo C.
Italy, Bologna
Alma Mater Studiorum Università Di Bologna
Oulmouden, Ahmad
France, Limoges
Université de Limoges
Statistics
Citations: 84
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.1016/j.ygeno.2009.11.003
ISSN:
08887543
e-ISSN:
10898646
Research Areas
Cancer
Genetics And Genomics