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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma
Oncogene, Volume 24, No. 47, Year 2005
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Description
The mechanisms that regulate induction of the antiapoptotic state and mitogenic signals in primary effusion lymphoma (PEL) are not well known. In efforts to identify novel approaches to block the proliferation of PEL cells, we found that curcumin (diferuloylmethane), a natural compound isolated from the plant Curcuma Ionga, inhibits cell proliferation and induces apoptosis in a dose dependent manner in several PEL cell lines. Such effects of curcumin appear to result from suppression of the constitutively active STAT3 through inhibition of Janus kinase 1 (JAK1). Our data also demonstrate that curcumin induces loss of mitochondrial membrane potential with subsequent release of cytochrome c and activation of caspase-3, followed by polyadenosin-5′-diphosphate-ribose polymerase (PARP) cleavage. Altogether, our findings suggest a novel function for curcumin, acting as a suppressor of JAK-1 and STAT3 activation in PEL cells, leading to inhibition of proliferation and induction of caspase-dependent apoptosis. Therefore, curcumin may have a future therapeutic role in PEL and possibly other malignancies with constitutive activation of STAT3. © 2005 Nature Publishing Group All rights reserved.
Authors & Co-Authors
Uddin, Shahab
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Hussain, Azhar R.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Manogaran, Pulicat Subramanian
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
al-Hussein, Khalid A.F.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Platanias, Leonidas C.
United States, Chicago
Northwestern University Feinberg School of Medicine
Gutiérrez, Marina Inés
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Bhatia, Kishor G.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
United States, Rockville
National Cancer Institute Nci
Statistics
Citations: 124
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1038/sj.onc.1208864
ISSN:
09509232
e-ISSN:
14765594
Research Areas
Cancer