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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prevalence and covariates of abnormal left ventricular geometry in never-treated hypertensive patients in Tanzania
Blood Pressure, Volume 23, No. 1, Year 2014
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Description
Aim. To assess prevalence, type and covariates of abnormal left ventricular (LV) geometry in untreated native Tanzanian patients with hypertension in relation to normotensive controls. Methods. Echocardiography was performed in 161 untreated hypertensive outpatients and 80 normotensive controls at a tertiary hospital in Tanzania. Hypertensive heart disease was defined as presence of increased LV mass or relative wall thickness (RWT). Results. The prevalence of hypertensive heart disease increased with the severity of hypertension and was on average 62.1% among patients and 12.5% in controls. In multivariate analyses, higher LV mass index was associated with higher systolic blood pressure (β = 0.28), body mass index (β = 0.20), peak early transmitral to medial mitral annulus velocity ratio (β = 0.16), and with lower stress-corrected midwall shortening (scMWS) (β = - 0.44) and estimated glomerular filtration rate (β = - 0.16), all p < 0.05. Higher RWT was associated with higher systolic blood pressure (β = 0.16), longer E-wave deceleration time (β = 0.23) and lower scMWS (β = - 0.66), irrespective of LV mass (all p < 0.05). Conclusion. Subclinical hypertensive heart disease is highly prevalent in untreated native hypertensive Tanzanians and associated with both systolic and diastolic LV dysfunction. Management of hypertension in Africans should include high focus on subclinical hypertensive heart disease. © 2014 Scandinavian Foundation for Cardiovascular Research.
Authors & Co-Authors
Chillo, Pilly
Norway, Bergen
Universitetet I Bergen
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Lwakatare, Johnson
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Rieck, Åshild E.
Norway, Bergen
Universitetet I Bergen
Lutale, Janet K.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Gerdts, Eva
Norway, Bergen
Universitetet I Bergen
Norway, Bergen
Haukeland Universitetssjukehus
Statistics
Citations: 12
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.3109/08037051.2013.791415
ISSN:
08037051
e-ISSN:
16511999
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Locations
Tanzania