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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A novel locus of enterocyte effacement (LEE) pathogenicity island inserted at pheV in bovine Shiga toxin-producing Escherichia coli strain O103:H2
FEMS Microbiology Letters, Volume 204, No. 1, Year 2001
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Description
We describe a locus of enterocyte effacement (LEE) which is part of a new pathogenicity island (PAI) detected in the bovine Shiga toxin-producing Escherichia coli strain RW1374 (O103:H2). This PAI is at least 80 kb in size and inserted in the vicinity of the pheV tRNA gene at 67 min of the E. coli chromosome. Furthermore, the PAI differs from the previously described LEEs by unique flanking regions at both sides, which harbor one copy each of an insertion element in an inverted orientation that is 96% identical to insertion site (IS)629. In addition, a 5-kb PAI-specific sequence downstream of the LEE core region and adjacent to the E. coli K12 region is duplicated upstream of the LEE core region as well. The duplicated sequences are more than 80% identical to each other and consist partially of prophage sequences. © 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
Authors & Co-Authors
Jores, Joerg
Germany, Hannover
Institut Für Mikrobiologie Und Tierseuchen
Kaper, James B.
United States, Baltimore
University of Maryland, Baltimore Umb
Wieler, Lothar H.
Germany, Hannover
Institut Für Mikrobiologie Und Tierseuchen
Statistics
Citations: 45
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1016/S0378-1097(01)00378-0
ISSN:
03781097
Research Areas
Genetics And Genomics