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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Endogenous morphine levels after laparoscopic versus open colectomy
British Journal of Surgery, Volume 97, No. 5, Year 2010
Notification
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Description
Background: Endogenous morphine may be a component of the acute-phase response to surgical trauma that affects both hospital stay and gastrointestinal motility. The purpose of this study was to assess the responses of endogenous morphine, stress hormones and cytokines following laparoscopic and open colectomy. Methods: Twenty patients who underwent a laparoscopic colectomy were compared with ten who had an open procedure. Data collected included operative blood loss, operating time and time to pass flatus. Plasma endogenous morphine was measured before and immediately after operation, and 3, 24 and 48 h later. Results: Age was comparable in the two groups. Operating time (mean 92.2 versus 61.3 min), time to tolerance of solid food (56.8 versus 103.6 h) and hospital stay (median 4 versus 6 days) were all significantly longer in the open group. Endogenous morphine levels rose immediately after open colectomy only and were higher than those after laparoscopic colectomy (8.69 versus 1.97 ng/ml; P < 0.001). Levels remained significantly higher in the laparoscopic group at 3 h (10.36 versus 0.52 ng/ml; P < 0.001) and 24 h, but were similar in both groups after 48 h. Conclusion: There is a greater degree of morphine synthesis after open than laparoscopic colectomy. Copyright © 2010 British Journal of Surgery Society Ltd.
Authors & Co-Authors
Madboulay, Khaled
Egypt, Alexandria
Faculty of Medicine
Senagore, Anthony J.
United States, East Lansing
Michigan State University
Delaney, Conor P.
United States, Cleveland
Case Western Reserve University
Statistics
Citations: 26
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1002/bjs.6987
ISSN:
00071323
e-ISSN:
13652168
Research Areas
Food Security
Health System And Policy