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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A 20-year longitudinal study of plasmodium ovale and plasmodium malariae prevalence and morbidity in a West African population
PLoS ONE, Volume 9, No. 2, Article e87169, Year 2014
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Description
Background: Plasmodium ovale and Plasmodium malariae have long been reported to be widely distributed in tropical Africa and in other major malaria-endemic areas of the world. However, little is known about the burden caused by these two malaria species. Methods and Findings: We did a longitudinal study of the inhabitants of Dielmo village, Senegal, between June, 1990, and December, 2010. We monitored the inhabitants for fever during this period and performed quarterly measurements of parasitemia. We analyzed parasitological and clinical data in a random-effect logistic regression model to investigate the relationship between the level of parasitemia and the risk of fever and to establish diagnostic criteria for P. ovale and P. malariae clinical attacks. The prevalence of P. ovale and P. malariae infections in asymptomatic individuals were high during the first years of the project but decreased after 2004 and almost disappeared in 2010 in relation to changes in malaria control policies. The average incidence densities of P. ovale and P. malariae clinical attacks were 0.053 and 0.093 attacks per person per year in children <15 years and 0.024 and 0.009 attacks per person per year in adults ≥15 years, respectively. These two malaria species represented together 5.9% of the malaria burden. Conclusions: P. ovale and P. malariae were a common cause of morbidity in Dielmo villagers until the recent dramatic decrease of malaria that followed the introduction of new malaria control policies. P. ovale and P. malariae may constitute an important cause of morbidity in many areas of tropical Africa. © 2014 Roucher et al.
Authors & Co-Authors
Roucher, Clémentine
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Rogier, Christophe
Senegal, Dakar
Institut Pasteur de Dakar
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Sokhna, Cheikh Sadibou
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Tall, Adama
Senegal, Dakar
Institut Pasteur de Dakar
Trape, Jean François
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Statistics
Citations: 87
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pone.0087169
e-ISSN:
19326203
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Senegal