Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Analysis of MHC genes in a Tunisian isolate with autoimmune thyroid diseases: Implication of TNF -308 gene polymorphism
Journal of Autoimmunity, Volume 23, No. 1, Year 2004
Notification
URL copied to clipboard!
Description
Autoimmune thyroid diseases (AITDs), which include Hashimoto thyroiditis (HT), Graves' disease (GD) and primary idiopathic myxoedema (PIM), are recognized as multifactorial diseases. In this study, we have examined single and haplotypic genetic variation across the major histocompatibility complex (MHC) in a Tunisian isolate with a high prevalence of AITDs (62 patients: 32 with GD, 9 with HT and 21 with PIM). Genotyping was performed for HLA class I and II alleles as well as polymorphisms within tumor necrosis factor (TNF), lymphotoxin α (TLα) and heat shock protein (HSP70-02 and HSP70-hom) genes. Our results showed association of HLA-A2-B50-TNF 2 haplotype with AITDs (p=0.045). Linkage analysis using Simwalk2 program has shown significant result with TNF -308 gene polymorphism (p=0.03). The FBAT has given evidence for genetic association with TNF -308 and HLA-DR gene polymorphisms. TNF 2 allele was associated with GD (p=0.0011), whereas TNF 1, HLA-DR11 and DR12 (p=0.0039, p=0.00089 and p=0.0056, respectively) were rather implicated in HT pathogenesis. Results found by TDT-STDT have confirmed the involvement of the TNF -308 gene polymorphism in AITD pathogenesis (p<10-9). © 2004 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Bougacha-Elleuch, Noura
Tunisia, Sfax
Faculty of Medicine of Sfax
REBAI, AHMED
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Mnif, Mouna Feki
Tunisia, Sfax
Chu Hedi-chaker
Makni, Hafedh
Tunisia, Sfax
Faculty of Medicine of Sfax
Tunisia, Sfax
Chu Hedi-chaker
Bellassouad, Mohamed
Tunisia, Sfax
Chu Hedi-chaker
Jouida, Jomaa
Unknown Affiliation
Abid, Mohamed
Tunisia, Sfax
Chu Hedi-chaker
Ayadi, Hammadi
Tunisia, Sfax
Faculty of Medicine of Sfax
Statistics
Citations: 33
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/j.jaut.2004.03.011
ISSN:
08968411
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study