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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
In vitro and in vivo activity of Aloe vera leaf exudate in experimental visceral leishmaniasis
Parasitology Research, Volume 102, No. 6, Year 2008
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Description
The leishmanicidal activity of Aloe vera leaf exudate (AVL) has been demonstrated in promastigotes and axenic amastigotes, but its effectiveness in animal models has not been evaluated. The presence of alkaloids, triterpenes, cyanidines, proanthocyanidines, tannins, and saponins in AVL was identified. Its effectiveness in four Leishmania donovani strains was studied both in promastigotes (IC50 ranged from 70-115 μg/ml) and amastigotes (IC50 ranged from 3.1-11.4 μg/ml). In amastigotes, the killing by AVL was facilitated through its induction of nitric oxide in leishmania-infected macrophages. The safety index was good as AVL up to 300 μg/ml remained non-toxic to monocytes and macrophages. In a L. donovani BALB/c mouse model, oral or subcutaneous administration of AVL (15 mg/kg body weight×5 days) reduced parasitemia by >90% in the liver, spleen, and bone marrow without impairment of hepatic and renal functions. Collectively, we conclude that AVL shows promising antileishmanial activity and may provide a new lead agent in the treatment of Leishmaniasis. © 2008 Springer-Verlag.
Authors & Co-Authors
Dutta, Avijit
India, Kolkata
Indian Institute of Chemical Biology
Taiwan, Taoyuan
Chang Gung University School of Medicine
Sarkar, Debjani
India, Kolkata
Institute of Post Graduate Medical Education and Research Kolkatta
Gurib-Fakim, Ameenah
Mauritius, Reduit
University of Mauritius
Mandal, Chitra
India, Kolkata
Indian Institute of Chemical Biology
Chatterjee, Mitali
India, Kolkata
Institute of Post Graduate Medical Education and Research Kolkatta
Statistics
Citations: 49
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1007/s00436-008-0899-2
ISSN:
09320113
Research Areas
Environmental
Health System And Policy