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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Late graft loss or death in pediatric liver transplantation: an analysis of the SPLIT database
American Journal of Transplantation, Volume 7, No. 9, Year 2007
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Description
Late graft loss (LGL) and late mortality (LM) following liver transplantation (LT) in children were analyzed from the studies of pediatric liver transplantation (SPLIT) database. Univariate and multivariate associations between pre- and postoperative factors and LGL and LM in 872 patients alive with their primary allografts 1 year after LT were reviewed. Thirty-four patients subsequently died (LM) and 35 patients underwent re-LT (LGL). Patients who survive the first posttransplant year had 5-year patient and graft survival rates of 94.2% and 89.2%, respectively. Graft loss after the first year was caused by rejection in 49% of the cases with sequelae of technical complications accounting for an additional 20% of LGL. LT for tumor, steroid resistant rejection, reoperation in the first 30 days and >5 admissions during the first posttransplant year were independently associated with LGL in multivariate analysis. Malignancy, infection, multiple system organ failure and posttransplant lymphoproliferative disease accounted for 61.8% of all late deaths after LT. LT performed for FHF and tumor were associated with LM. Patients who are at or below the mean for weight at the time of transplant were also at an increased risk of dying. Frequent readmission was also found to be associated with LM. © 2007 The Authors.
Authors & Co-Authors
Mazariegos, George Vincent
United States, Pittsburgh
Upmc Children’s Hospital of Pittsburgh
United States, Pittsburgh
University of Pittsburgh Medical Center
Dünn, Stephen P.
United States, Rockville
The Emmes Corporation
United States, Wilmington
Alfred I. Dupont Hospital for Children
Jonas, Maureen M.F.
United States, Rockville
The Emmes Corporation
United States, Boston
Boston Children's Hospital
Heffron, Thomas G.
United States, Rockville
The Emmes Corporation
United States, Atlanta
Children’s Healthcare of Atlanta
Bucuvalas, John C.
United States, Rockville
The Emmes Corporation
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
Sokol, Ronald J.
United States, Rockville
The Emmes Corporation
United States, Denver
Children's Hospital Denver
Humar, Abhinav P.
United States, Rockville
The Emmes Corporation
United States, Minneapolis
University of Minnesota Twin Cities
Alonso, Estella M.
United States, Rockville
The Emmes Corporation
Ng, Vicky Lee
United States, Rockville
The Emmes Corporation
Canada, Toronto
Hospital for Sick Children University of Toronto
Schwarz, Kathleen Brogan
United States, Rockville
The Emmes Corporation
United States, Baltimore
The Johns Hopkins Hospital
Eshun, John K.
United States, Rockville
The Emmes Corporation
United States, Memphis
Le Bonheur Children's Hospital
So, Samuel S.K.
United States, Rockville
The Emmes Corporation
United States, Stanford
Stanford Healthcare
Emre, Sükrü H.
United States, Rockville
The Emmes Corporation
United States, New York
The Mount Sinai Medical Center
Shneider, Benjamin L.
United States, Rockville
The Emmes Corporation
United States, New York
The Mount Sinai Medical Center
Kerkar, Nanda N.
United States, Rockville
The Emmes Corporation
United States, New York
The Mount Sinai Medical Center
Karpen, Saul J.
United States, Rockville
The Emmes Corporation
United States, Houston
Texas Children's Hospital
Goss, John Alan
United States, Rockville
The Emmes Corporation
United States, Houston
Texas Children's Hospital
Fishman, Douglas Shawn
United States, Rockville
The Emmes Corporation
United States, Houston
Texas Children's Hospital
McLin, Valérie Anne
United States, Rockville
The Emmes Corporation
United States, Houston
Texas Children's Hospital
Aloia, Thomas A.
United States, Rockville
The Emmes Corporation
United States, Houston
Texas Children's Hospital
Kneteman, Norman M.
United States, Rockville
The Emmes Corporation
Canada, Edmonton
University of Alberta
Lobritto, Steven J.
United States, Rockville
The Emmes Corporation
United States, New York
New York Presbyterian Hospital
Shepherd, Ross William
United States, Rockville
The Emmes Corporation
United States, St. Louis
St. Louis Children's Hospital
Lavine, Joel Edward
United States, Rockville
The Emmes Corporation
United States, La Jolla
University of California, San Diego
Khanna, Ajai K.
United States, Rockville
The Emmes Corporation
United States, La Jolla
University of California, San Diego
Horslen, Simon Peter
United States, Rockville
The Emmes Corporation
United States, Seattle
University of Washington
Knechtle, Stuart J.
United States, Rockville
The Emmes Corporation
United States, Madison
University of Wisconsin-madison
Gonzâlez-Peralta, Regino P.
United States, Rockville
The Emmes Corporation
United States, Gainesville
University of Florida
Rosenthal, Philip Jon
United States, Rockville
The Emmes Corporation
United States, San Francisco
University of California, San Francisco
Langnas, Alan N.N.
United States, Rockville
The Emmes Corporation
United States, Omaha
University of Nebraska Medical Center
Botha, Jean F.
United States, Rockville
The Emmes Corporation
United States, Omaha
University of Nebraska Medical Center
Desai, Dev M.
United States, Rockville
The Emmes Corporation
United States, Durham
Duke University Medical Center
Statistics
Citations: 141
Authors: 32
Affiliations: 41
Identifiers
Doi:
10.1111/j.1600-6143.2007.01893.x
ISSN:
16006143
Research Areas
Cancer
Health System And Policy
Maternal And Child Health