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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Profiling of human acquired immunity against the salivary proteins of phlebotomus papatasi reveals clusters of differential immunoreactivity
American Journal of Tropical Medicine and Hygiene, Volume 90, No. 5, Year 2014
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Description
Phlebotomus papatasi sand flies are among the primary vectors of Leishmania major parasites from Morocco to the Indian subcontinent and from southern Europe to central and eastern Africa. Antibody-based immunity to sand fly salivary gland proteins in human populations remains a complex contextual problem that is not yet fully understood. We profiled the immunoreactivities of plasma antibodies to sand fly salivary gland sonicates (SGSs) from 229 human blood donors residing in different regions of sand fly endemicity throughout Jordan and Egypt as well as 69 US military personnel, who were differentially exposed to P. papatasi bites and L. major infections in Iraq. Compared with plasma from control region donors, antibodies were significantly immunoreactive to five salivary proteins (12, 26, 30, 38, and 44 kDa) among Jordanian and Egyptian donors, with immunoglobulin G4 being the dominant anti-SGS isotype. US personnel were significantly immunoreactive to only two salivary proteins (38 and 14 kDa). Using k-means clustering, donors were segregated into four clusters distinguished by unique immunoreactivity profiles to varying combinations of the significantly immunogenic salivary proteins. SGS-induced cellular proliferation was diminished among donors residing in sand fly-endemic regions. These data provide a clearer picture of human immune responses to sand fly vector salivary constituents. Copyright © 2014 by The American Society of Tropical Medicine and Hygiene.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4015589/bin/SD1.pdf
Authors & Co-Authors
Geraci, Nicholas S.
United States, Notre Dame
University of Notre Dame
Mukbel, Rami M.
United States, Notre Dame
University of Notre Dame
Kemp, Michael T.
United States, Notre Dame
University of Notre Dame
Wadsworth, Mariha
United States, Notre Dame
University of Notre Dame
Lesho, Emil Patrick
United States, Bethesda
Walter Reed National Military Medical Center
United States, Silver Spring
Walter Reed Army Institute of Research
Stayback, Gwen M.
United States, Notre Dame
University of Notre Dame
Champion, Matthew M.
United States, Notre Dame
University of Notre Dame
Bernard, Megan A.
United States, Notre Dame
University of Notre Dame
Abo-Shehada, Mahamoud
Jordan, Irbid
Jordan University of Science and Technology
Coutinho-Abreu, I. Vieira
United States, Manhattan
Kansas State University
Ramalho-Ortigão, Marcelo
United States, Manhattan
Kansas State University
Hanafi, Hanafi A.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Fawaz, Emadeldin Y.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
El-Hossary, Shabaan S.I.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Wortmann, Glenn W.
United States, Bethesda
Walter Reed National Military Medical Center
Hoel, David F.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
McDowell, Mary Ann
United States, Notre Dame
University of Notre Dame
Statistics
Citations: 17
Authors: 17
Affiliations: 6
Identifiers
Doi:
10.4269/ajtmh.13-0130
ISSN:
00029637
Research Areas
Health System And Policy
Study Locations
Egypt
Morocco