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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Association of STAT4 with rheumatoid arthritis: A replication study in three European populations
Arthritis and Rheumatism, Volume 58, No. 7, Year 2008
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Description
Objective. This study was undertaken to investigate the previously reported association of the STAT4 polymorphism rs7574865 with rheumatoid arthritis (RA) in 3 different European populations from Spain, Sweden, and The Netherlands, comprising a total of 2,072 patients and 2,474 controls. Methods. Three different cohorts were included in the study: 923 RA patients and 1,296 healthy controls from Spain, 273 RA patients and 285 healthy controls from Sweden, and 876 RA patients and 893 healthy controls from The Netherlands. DNA from patients and controls was obtained from peripheral blood. Samples were genotyped for the STAT4 single-nucleotide polymorphism rs7574865 using a TaqMan 5′-allele discrimination assay. The chi-square test was performed to compare allele and genotype distributions. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Results. We observed a significantly increased frequency of the minor T allele in RA patients compared with healthy controls in the Spanish population (24.8% versus 20.8%; P = 0.001, OR 1.26 [95% CI 1.09-1.45]). This association was confirmed in both the Swedish population (P = 0.03, OR 1.35 [95% CI 1.03-1.77]) and the Dutch population (P = 0.03, OR 1.45 [95% CI 1.21-1.73]). The overall P value for all 3 populations was 9.79 × 10 -6 (OR 1.25 [95% CI 1.13-1.37]). No association between rs7574865 and the presence of rheumatoid factor or anti-cyclic citrullinated peptide autoantibodies was observed. A meta-analysis of all published STAT4 associations revealed an OR of 1.25 (95% CI 1.19-1.33) (P = 1 × 10 -5). Conclusion. Our findings indicate an association between the STAT4 polymorphism rs7574865 and RA in 3 different populations, from Spain, Sweden, and The Netherlands, thereby confirming previous data. © 2008, American College of Rheumatology.
Authors & Co-Authors
Orozco, Gisela
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Alizadeh, Behrooz Z.
Netherlands, Utrecht
University Medical Center Utrecht
González-Gay, Miguel Ángel
Spain, Lugo
Complejo Hospitalario Xeral Calde
Balsa, Alejando
Spain, Madrid
Hospital Universitario la Paz
Pascual-Salcedo, Dora
Spain, Madrid
Hospital Universitario la Paz
Fernàndez-Gutiérrez, Benjamín
Spain, Madrid
Hospital Clínico San Carlos
Gónzalez-Escribano, María Francisca
Spain, Sevilla
Hospital Universitario Virgen Del Rocío
van Riel, Piet L.C.M.
Netherlands, Nijmegen
Radboud University Medical Center
Barrera, Pilar
Netherlands, Nijmegen
Radboud University Medical Center
Coenen, Marieke J.H.
Netherlands, Nijmegen
Radboud University Medical Center
Radstake, Timothy R.D.J.
Netherlands, Nijmegen
Radboud University Medical Center
Wijmenga, Cisca
Netherlands, Utrecht
University Medical Center Utrecht
Netherlands, Groningen
Rijksuniversiteit Groningen
Koeleman, Bobby P.C.
Netherlands, Utrecht
University Medical Center Utrecht
Alarcón-Riquelme, Marta Eugenia
Sweden, Uppsala
Uppsala Universitet
Martin, Javier
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Statistics
Citations: 115
Authors: 15
Affiliations: 10
Identifiers
Doi:
10.1002/art.23549
ISSN:
00043591
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Systematic review