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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses
Blood, Volume 112, No. 13, Year 2008
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Description
The C-type lectin receptor dectin-1 functions as a pattern recognition receptor for β-glucans and signals via Syk kinase but independently of the Toll-like receptor (TLR) pathway to regulate expression of innate response genes. Dectin-1 signaling can promote activation of dendritic cells (DCs), rendering them competent to prime Th1 and Th17 responses. Here we show that dectin-1-activated DCs can also prime cytotoxic T-lymphocyte (CTL) responses. DCs exposed to a dectin-1 agonist induced antigen-specific expansion of TCR transgenic CD8+ T cells and their differentiation into CTLs in vitro. Dectin-1 agonist also acted as an adjuvant for CTL crosspriming in vivo, eliciting potent CTL responses that protected mice from tumor challenge. In vitro but not in vivo, CTL crosspriming was dependent on IL-12 p70, which was produced by dectin-1-activated DCs in response to IFN-γ secreted by newly activated CD8+ T cells. The dectin-1/Syk pathway is thus able to couple innate immune recognition of β-glucans to all branches of the adaptive immune system, including CD4+ T-helper cells, B cells, and CD8+ cytotoxic T cells. These data highlight the ability of non-TLR receptors to bridge innate and adaptive immunity and suggest that dectin-1 agonists may constitute useful adjuvants for immunotherapy and vaccination. © 2008 by The American Society of Hematology.
Authors & Co-Authors
LeibundGut-Landmann, Salomé
United Kingdom, London
Cancer Research uk
Osorio, Fabiola
United Kingdom, London
Cancer Research uk
Brown, Gordon D.A.
South Africa, Cape Town
University of Cape Town
Reis E Sousa, Caetano E.
United Kingdom, London
Cancer Research uk
Statistics
Citations: 4
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1182/blood-2008-05-158469
ISSN:
00064971
Research Areas
Cancer