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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Comparative effects of different cellulosic-based directly compressed orodispersable tablets on oral bioavailability of famotidine
Carbohydrate Polymers, Volume 77, No. 4, Year 2009
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Description
Famotidine is a potent H2-receptor antagonist most commonly used by elderly patients. Orodispersible tablets (ODT) are gaining popularity over conventional tablets due to their convenience and suitability for patients having dysphagia. The purpose of this study is to prepare famotidine ODT using the economic direct-compression method. A 32 full factorial design was used to evaluate the influence of different excipients on the properties and in vitro dissolution of famotidine ODT. Two factors were studied for their qualitative effects, namely, disintegrants and diluents. Disintegrants were studied in three levels viz. Ac-Di-Sol, sodium starch glycolate (Primojel) and low-substituted hydroxypropyl cellulose (L-HPC). Fillers were studied in three levels viz. mannitol, spray dried lactose and Avicel PH 101. The ODTs were prepared by direct compression and were evaluated for hardness, drug content, uniformity of weight, in vitro disintegration time, oral disintegration time, wetting time and in vitro dissolution. Maximum dissolution and minimum oral disintegration time (11.4 s) were observed in F7 prepared using L-HPC and mannitol. Furthermore, in human volunteers it showed significant increase in bioavailability compared to Servipep® with mean AUC(0-∞) 117.1 ng/ml and 82.71 ng/ml, respectively, and its relative bioavailability was 141.57%. Hence, ODT (F7) could possibly be used to overcome the drawbacks of conventional famotidine tablets in elderly patients with significant increase in oral bioavailability. © 2009 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Abdelbary, Ahmed
Egypt, Cairo
Faculty of Pharmacy
Elshafeey, Ahmed Hassen
Egypt, Cairo
Faculty of Pharmacy
Zidan, G.
Egypt, Cairo
Misr International University
Statistics
Citations: 66
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1016/j.carbpol.2009.02.030
ISSN:
01448617
Research Areas
Health System And Policy
Study Approach
Qualitative