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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Safety, tolerability, and efficacy of continuous transdermal dopaminergic stimulation with rotigotine patch in early-stage idiopathic Parkinson disease
Clinical Neuropharmacology, Volume 28, No. 3, Year 2005
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Description
Rotigotine is a new dopamine agonist with transdermal patch formulation for the treatment of Parkinson disease. The aim of this study was to investigate safety and efficacy of rotigotine in patients with early-stage Parkinson disease. In this open-label, dose-escalation, safety and efficacy study, 31 patients in the early stages of idiopathic Parkinson disease received rotigotine to a maximum of 18.0 mg/day. Of the 29 patients who completed the 28-day treatment phase, 24 were maintained at the maximum dose level. The drug was well tolerated, and skin reactions were mild. A statistically significant improvement in UPDRS I, II, and III scores was observed from baseline to end of treatment for the 29 subjects who completed the trial. Mean improvement (± standard deviation) was -0.41 ± 0.78 on UPDRS I (P = 0.0078), -2.76 ± 3.31 on UPDRS II (P = 0.0001), and -4.62 ± 5.32 on UPDRS III (P < 0.0001). When results were stratified by maximum dose achieved, significant improvements were seen on all 3 subscores for patients achieving the maximum dose. These data suggest that rotigotine is a safe, well-tolerated, and effective treatment for early-stage Parkinson disease. Copyright © 2005 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Güldenpfennig, Werner M.
South Africa, Pretoria
Little Company of Mary Medical Centre
Poole, Kathryn H.
United States, Research Triangle Park
Schwarz Biosciences
Sommerville, Kenneth W.
United States, Research Triangle Park
Schwarz Biosciences
Boroojerdi, Babak
Germany, Monheim
Schwarz Pharma ag
Statistics
Citations: 56
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1097/01.wnf.0000162228.00154.ba
ISSN:
03625664