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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Secondary mutations in the protease region of human immunodeficiency virus and virologic failure in drug-naive patients treated with protease inhibitor-based therapy
Journal of Infectious Diseases, Volume 184, No. 8, Year 2001
Notification
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Description
The role of mutations in protease (PR) and reverse-transcriptase (RT) of human immunodeficiency virus (HIV) in predicting virologic failure was assessed in 248 antiretroviral-naive HIV-positive patients who began a PR inhibitor-containing antiretroviral regimen. Genotypic testing was performed on plasma samples stored before the start of therapy. Twenty-seven patients (10.9%) had mutations in the RT, 5 (2%) carried primary mutations in the PR, and 131 (52.8%) showed only secondary PR mutations. Virologic failure at week 24 occurred in 62 (25.0%) of 248 patients. There was a statistically significant correlation between virologic failure and the number of PR mutations (P=.04, X2 test). Mutations at codons 10 and 36 of PR (present in 39.3% and 40.0% of patients in whom treatment failed, respectively) were identified by stepwise logistic regression as the strongest predictors of virologic failure (odds ratio, 2.20; 95% confidence interval, 1.30-3.75; P=.004). If confirmed in independent studies, this result may justify the increased use of HIV genotyping in drug-naive patients requiring antiretroviral therapy. © 2001 by the Infectious Diseases Society of America.
Authors & Co-Authors
Perno, Carlo Federico
Italy, Milan
Fondazione Istituto Diricovero
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Cozzi-Lepri, Alessandro
Italy, Milan
Fondazione Istituto Diricovero
Balotta, Claudia
Italy, Milan
Università Degli Studi Di Milano
Forbici, Federica
Italy, Milan
Fondazione Istituto Diricovero
Bertoli, A.
Italy, Milan
Fondazione Istituto Diricovero
Pezzotti, P.
Italy, Rome
Italian Institute of Health
Phillips, Andrew N.
Italy, Milan
Fondazione Istituto Diricovero
Monno, Laura
Italy, Bari
Università Degli Studi Di Bari Aldo Moro
Ippolito, Giuseppe
Italy, Milan
Fondazione Istituto Diricovero
D'Arminio Monforte, Antonella D.
Italy, Milan
Università Degli Studi Di Milano
Scalise, Giorgio
Unknown Affiliation
Costantini, Alberto
Unknown Affiliation
Suter, Fredy
Unknown Affiliation
Carosi, Giaampiero
Unknown Affiliation
Castelli, Francesco
Unknown Affiliation
Rizzardini, Giuliano
Unknown Affiliation
Pusterla, Luigi
Unknown Affiliation
Pan, Angelo
Unknown Affiliation
Viganò, Paolo
Unknown Affiliation
Mazzotta, Francesco
Unknown Affiliation
Lo Caputo, Sergio
Unknown Affiliation
Tundo, Paolo
Unknown Affiliation
Lazzarin, Adriano
Unknown Affiliation
Milazzo, Francesco
Unknown Affiliation
Mussini, Cristina
Unknown Affiliation
Chirianni, Antonio
Unknown Affiliation
Statistics
Citations: 106
Authors: 26
Affiliations: 9
Identifiers
Doi:
10.1086/323604
ISSN:
00221899
Research Areas
Infectious Diseases
Study Design
Case-Control Study