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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Plasma cytokines and chemokines differentiate between active disease and non-active tuberculosis infection
Journal of Infection, Volume 66, No. 4, Year 2013
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Description
Objectives: To analyse cytokines and chemokines from unstimulated plasma samples for detection of active TB disease, latent TB, discriminating active TB cases from latently infected contacts and for monitoring anti TB treatment. Method: We analysed ex vivo plasma samples from 33 TB patients (17 HIV negative and 16 HIV positive) and 30 healthy household contacts with Luminex. Result: We found statistically significant differences (p < 0.05) in median plasma concentrations of EGF, fractalkine, IFN-γ, IL-4, MCP-3 and IP-10 between contacts and TB patients. Single cytokines or chemokines predict with an area under the Receiver Operating Characteristic (ROC) curve of 0.59 for VEGF to 0.98 for IP 10 while a combination of fractalkine, IFN-g, IL-4, IP-10 and TNF identified 96.87% of TB cases and 100% of household contacts. However, none of the cytokines were significantly different in QFT positive and QFT negative contacts (p > 0.05). HIV does not affect the median plasma level of any of the cytokines or chemokines and there was not significant difference between HIV positive and HIV negative TB patients (p > 0.05) in any of the cytokines or chemokines. The median plasma concentrations of IFN-γ, IL-4, MCP-3, MIP-1β and IP-10 were significantly different (p < 0.05) before treatment and after treatment. Conclusion: Plasma cytokines and chemokines could be used as immunological markers for diagnosing active TB disease and for monitoring effective antituberculosis therapy. © 2012 The British Infection Association.
Authors & Co-Authors
Mihret, Adane
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Ethiopia, Addis Ababa
Addis Ababa University
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Bekele, Yonas Y.
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Bobosha, Kidist
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Kidd, Martin
South Africa, Stellenbosch
Stellenbosch University
Aseffa, Abraham
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Howe, Rawleigh Craig
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Walzl, Gerhard
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Statistics
Citations: 101
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/j.jinf.2012.11.005
ISSN:
01634453
e-ISSN:
15322742
Research Areas
Infectious Diseases