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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Switching to dual/monotherapy determines an increase in CD8+ in HIV-infected individuals: An observational cohort study
BMC Medicine, Volume 16, No. 1, Article 79, Year 2018
Notification
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Description
Background: The CD4/CD8 ratio has been associated with the risk of AIDS and non-AIDS events. We describe trends in immunological parameters in people who underwent a switch to monotherapy or dual therapy, compared to a control group remaining on triple antiretroviral therapy (ART). Methods: We included patients in Icona who started a three-drug combination ART regimen from an ART-naïve status and achieved a viral load ≤ 50 copies/mL; they were subsequently switched to another triple or to a mono or double regimen. Standard linear regression at fixed points in time (12-24 months after the switch) and linear mixed model analysis with random intercepts and slopes were used to compare CD4 and CD8 counts and their ratio over time according to regimen types (triple vs. dual and vs. mono). Results: A total of 1241 patients were included; 1073 switched to triple regimens, 104 to dual (72 with 1 nucleoside reverse transcriptase inhibitor (NRTI), 32 NRTI-sparing), and 64 to monotherapy. At 12 months after the switch, for the multivariable linear regression the mean change in the log10 CD4/CD8 ratio for patients on dual therapy was -0.03 (95% confidence interval (CI) -0.05, -0.0002), and the mean change in CD8 count was +99 (95% CI +12.1, +186.3), taking those on triple therapy as reference. In contrast, there was no evidence for a difference in CD4 count change. When using all counts, there was evidence for a significant difference in the slope of the ratio and CD8 count between people who were switched to triple (points/year change ratio = +0.056, CD8 = -25.7) and those to dual regimen (ratio = -0.029, CD8 = +110.4). Conclusions: We found an increase in CD8 lymphocytes in people who were switched to dual regimens compared to those who were switched to triple. Patients on monotherapy did not show significant differences. The long-term implications of this difference should be ascertained. © 2018 The Author(s).
Authors & Co-Authors
Mussini, Cristina
Italy, Modena
Azienda Ospedaliero - Universitaria Di Modena
Lorenzini, Patrizia
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Cozzi-Lepri, Alessandro
United Kingdom, London
University College London
Rusconi, Stefano
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Gori, Andrea
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Nozza, Silvia
Italy, Milan
Irccs Ospedale San Raffaele
Lichtner, Miriam
Italy, Rome
Sapienza Università Di Roma
Antinori, Andrea
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Cossarizza, Andrea
Italy, Modena
Università Degli Studi Di Modena e Reggio Emilia
D'Arminio Monforte, Antonella D.
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Castagna, Antonella
Unknown Affiliation
Castelli, Francesco
Unknown Affiliation
Cauda, Roberto
Unknown Affiliation
Di Perri, Giovanni
Unknown Affiliation
Galli, Massimo
Unknown Affiliation
Iardino, Rosaria
Unknown Affiliation
Ippolito, Giuseppe
Unknown Affiliation
Lazzarin, Adriano
Unknown Affiliation
Perno, Carlo Federico
Unknown Affiliation
Rezza, Giovanni
Unknown Affiliation
Viale, Pierluigi
Unknown Affiliation
Ceccherini-Silberstein, Francesca
Unknown Affiliation
Girardi, Enrico
Unknown Affiliation
Lo Caputo, Sergio
Unknown Affiliation
Puoti, Massimo
Unknown Affiliation
Andreoni, Massimo G.
Unknown Affiliation
Ammassari, Adriana
Unknown Affiliation
Balotta, Claudia
Unknown Affiliation
Bandera, Alessandra
Unknown Affiliation
Bonfanti, Paolo
Unknown Affiliation
Bonora, Stefano
Unknown Affiliation
Borderi, Marco
Unknown Affiliation
Calcagno, A.
Unknown Affiliation
Calza, Leonardo
Unknown Affiliation
Capobianchi, Maria Rosaria
Unknown Affiliation
Cingolani, A.
Unknown Affiliation
Cinque, P.
Unknown Affiliation
De Luca, Andrea
Unknown Affiliation
Di Biagio, Antonio
Unknown Affiliation
Gianotti, Nicola
Unknown Affiliation
Guaraldi, Giovanni
Unknown Affiliation
Lapadula, Giovanni
Unknown Affiliation
Maggiolo, Franco
Unknown Affiliation
Monno, Laura
Unknown Affiliation
Quiròs-Roldan, Eugenia
Unknown Affiliation
Santoro, Maria Mercedes
Unknown Affiliation
Saracino, Annalisa L.
Unknown Affiliation
Zaccarelli, Mauro
Unknown Affiliation
Fanti, Iuri
Unknown Affiliation
Galli, Luisa
Unknown Affiliation
Rodano’, A.
Unknown Affiliation
Shanyinde, Milensu
Unknown Affiliation
Tavelli, Alessandro
Unknown Affiliation
Carrara, Stefania
Unknown Affiliation
Di Caro, Antonino
Unknown Affiliation
Quartu, Serena
Unknown Affiliation
Giacometti, Andrea R.
Unknown Affiliation
Angarano, Gioacchino
Unknown Affiliation
Verucchi, Gabriella
Unknown Affiliation
Quirino, Tiziana
Unknown Affiliation
Cacopardo, Bruno Santi
Unknown Affiliation
Celesia, Benedetto Maurizio
Unknown Affiliation
Segala, D.
Unknown Affiliation
Viscoli, Claudio
Unknown Affiliation
Mastroianni, Claudio Maria
Unknown Affiliation
Rizzardini, Giuliano
Unknown Affiliation
Ridolfo, Anna Lisa
Unknown Affiliation
Tincati, Camilla
Unknown Affiliation
Chirianni, Antonio
Unknown Affiliation
Cattelan, Anna María
Unknown Affiliation
Cascio, Antonio
Unknown Affiliation
Colomba, Claudia
Unknown Affiliation
Parruti, Giustino
Unknown Affiliation
Sozio, Federica
Unknown Affiliation
Cristaudo, Antonio
Unknown Affiliation
Vullo, Vincenzo
Unknown Affiliation
Acinapura, Rosa
Unknown Affiliation
Baldin, Gianmaria
Unknown Affiliation
Cicalini, Stefania
Unknown Affiliation
Latini, Alessandra
Unknown Affiliation
Vergori, Alessandra
Unknown Affiliation
Rossetti, Barbara
Unknown Affiliation
Caramello, Pietro
Unknown Affiliation
Orofino, Giancarlo
Unknown Affiliation
Bassetti, Matteo
Unknown Affiliation
Pellizzer, Giampietro P.
Unknown Affiliation
Manfrin, Vinicio
Unknown Affiliation
Statistics
Citations: 24
Authors: 87
Affiliations: 7
Identifiers
Doi:
10.1186/s12916-018-1046-2
ISSN:
17417015
Research Areas
Infectious Diseases
Study Design
Randomised Control Trial
Cohort Study
Study Approach
Quantitative