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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Efficacy of nebulized fluticasone propionate compared with oral prednisolone in children with an acute exacerbation of asthma
Respiratory Medicine, Volume 94, No. 12, Year 2000
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Description
The aim of the present study was to investigate the efficacy and safety of nebulized fluticasone propionate (FP NebulesTM) compared with oral soluble prednisolone in children with an acute exacerbation of asthma. The study used an international, multi-centre, randomized, double-blind, parallel group design. Three hundred and twenty-one patients, aged 4-16 years old, who presented with an acute exacerbation of asthma, were randomly allocated to either nebulized FP (1 mg b.d.) or oral prednisolone (2 mg kg-1 day-1 for 4 days then 1 mg kg-1 day-1 for 3 days) for 7 days. Patients in the FP group showed a significantly greater increase in diary card morning peak expiratory flow (PEF) over 7 days compared with patients in the prednisolone group (difference=9.51 min-1, CI=2.1, 16.8, P=0.034). Similar increases for both treatments were shown for evening PEF. Clinic PEF improved with both treatments, but was significantly greater in patients taking FP after 7 days (difference=11.4 lmin-1, CI=2.8, 20.0, P=0.029). Both treatments reduced symptom scores to a similar extent. The two treatments were well tolerated, and there was no difference in the incidence of adverse events. The present study demonstrated that nebulized FP is at least as effective as oral prednisolone in the treatment of children presenting with an acute exacerbation of asthma. © 2000 Harcourt Publishers Ltd.
Authors & Co-Authors
Manjra, Ahmed Ismail
South Africa, Westville
Westville Hospital
Price, J.
United Kingdom, London
King's College Hospital
Lenney, W.
United Kingdom, Stoke-on-trent
Royal Stoke University Hospital
Hughes, Sara H.
United Kingdom, Brentford
Glaxosmithkline Plc.
Barnacle, H.
United Kingdom, Brentford
Glaxosmithkline Plc.
Statistics
Citations: 44
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1053/rmed.2000.0952
ISSN:
09546111
Research Areas
Disability
Health System And Policy
Maternal And Child Health
Study Design
Cohort Study