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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Endotoxins and inflammation in hemodialysis patients
Hemodialysis International, Volume 17, No. 3, Year 2013
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Description
Long-term endotoxin challenge may promote frequent complications in dialysis patients, namely malnutrition, chronic inflammation, and atherosclerosis, which are recognized as the so-called MIA syndrome. Circulating soluble vascular cell adhesion molecule-1 (sVCAM-1) levels may be used to determine the stage of atherosclerosis. This study aimed to assess endotoxin level in hemodialysis (HD) patients and its role in inducing inflammation. The study was conducted on 50 HD patients, chosen from four dialysis centers in Alexandria. Serum blood samples were collected for the determination of albumin and C-reactive protein (CRP), and whole blood samples were used for the measurement of hemoglobin level. A heparinized whole blood sample was taken postdialysis for endotoxin assay by limulus amebocyte lysate test, and in addition to sVCAM-1 was estimated using enzyme-linked immunosorbent assay. The mean endotoxin level was 76.30pg/mL;80% exhibited values higher than 60pg/mL. Half the studied patients had CRP values that exceeded the upper limit of the laboratory reference range (<6.0mg/L). A statistically significant correlation was found between endotoxin and CRP levels (r = 0.47, P = 0.001). The mean pre-HD level of VCAM was 1851.00ng/mL, while the mean post-HD level was 2829.00ng/mL with statistically significant correlation (r = 0.354, P = 0.012) and it also correlated significantly with endotoxin as well as CRP levels. Endotoxemia may play an important role in the aggravation of endothelial dysfunction in HD patients as indicated by the post-HD rise in sVCAM-1. © 2013 The Authors. Hemodialysis International © 2013 International Society for Hemodialysis.
Authors & Co-Authors
El-Koraie, Ahmed F.
Egypt, Alexandria
Faculty of Medicine
Naga, Yasmine Salah
Egypt, Alexandria
Faculty of Medicine
Saaran, Amina M.
Egypt, Alexandria
Faculty of Medicine
Farahat, Nahla G.
Egypt, Alexandria
Faculty of Medicine
Hazzah, Walaa Ali
Egypt, Alexandria
High Institute of Public Health
Statistics
Citations: 18
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1111/hdi.12007
ISSN:
14927535
e-ISSN:
15424758
Research Areas
Food Security
Noncommunicable Diseases