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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response
Acta Tropica, Volume 92, No. 3, Year 2004
Notification
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Description
C57BL/6 mice deficient in one or two copies of the gene for tumor necrosis factor alpha (TNF-α) were more susceptible to Trypanosoma congolense infection than their resistant, wild-type counterparts. The number of TNF-α genes was correlated with the capacity to control parasitaemia and with survival time. Absence of TNF-α resulted in a diminished capacity to form germinal centres in lymph nodes and spleen. Since germinal centres are involved in antibody production and affinity maturation, the susceptibility of the TNF-α-deficient mice could have been due to this secondary defect. Despite the lack of the germinal centres, the antibody responses to internal and exposed trypanosome antigens and to non-trypanosome antigens were not significantly different. Also the relative avidities measured in infected sera did not significantly differ between the two mouse strains. These data suggest that the role of TNF-α in control of T. congolense was not due to its role in the development of an antibody response. © 2004 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Naessens, Jan
Kenya, Nairobi
International Livestock Research Institute Nairobi
Kitani, Hiroshi
Japan, Tsukuba
National Institute of Animal Health, Naro
Momotani, Eiichi
Japan, Tsukuba
National Institute of Animal Health, Naro
Sekikawa, Kenji
Japan, Tsukuba
Institute of Agrobiological Sciences, Naro
Nthale, Joseph M.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Iraqi, Fuad A.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Statistics
Citations: 27
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.actatropica.2004.05.015
ISSN:
0001706X
Research Areas
Cancer
Genetics And Genomics