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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Latent class analysis of the Yale-Brown Obsessive-Compulsive Scale symptoms in obsessive-compulsive disorder
Comprehensive Psychiatry, Volume 52, No. 3, Year 2011
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Description
Objective: Obsessive-compulsive disorder (OCD) is phenomenologically heterogeneous, and findings of underlying structure classification based on symptom grouping have been ambiguous to date. Variable-centered approaches, primarily factor analysis, have been used to identify homogeneous groups of symptoms; but person-centered latent methods have seen little use. This study was designed to uncover sets of homogeneous groupings within 1611 individuals with OCD based on symptoms. Method: Latent class analysis models using 61 obsessive-compulsive symptoms collected from the Yale-Brown Obsessive-Compulsive Scale were fit. Relationships between latent class membership and treatment response, sex, symptom severity, and comorbid tic disorders were tested for relationship to class membership. Results: Latent class analysis models of best fit yielded 3 classes. Classes differed only in frequency of symptom endorsement. Classes with higher symptom endorsement were associated with earlier age of onset, being male, higher Yale-Brown Obsessive-Compulsive Scale symptom severity scores, and comorbid tic disorders. There were no differences in treatment response between classes. Conclusions: These results provide support for the validity of a single underlying latent OCD construct, in addition to the distinct symptom factors identified previously via factor analyses. © 2011 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Delucchi, Kevin L.
United States, San Francisco
University of California, San Francisco
Katerberg, Hilga
Netherlands, Groningen
Universitair Medisch Centrum Groningen
South Africa, Stellenbosch
Stellenbosch University
Stewart, S. Evelyn
United States, Boston
Massachusetts General Hospital
United States, Belmont
Mclean Hospital
Denys, Damiaan A.J.P.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Netherlands, Amsterdam
Nederlands Herseninstituut
Lochner, Christine
South Africa, Stellenbosch
Stellenbosch University
Stack, Denise E.
United States, Belmont
Mclean Hospital
den Boer, Johan A.D.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Van Balkom, Anton J.L.M.Ton
Netherlands, Utrecht
Universiteit Utrecht
Jenike, Michael A.
United States, Boston
Massachusetts General Hospital
United States, Belmont
Mclean Hospital
Stein, Dan J.
South Africa, Stellenbosch
Stellenbosch University
South Africa, Cape Town
University of Cape Town
Cath, Daniëlle C.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Netherlands, Utrecht
Universiteit Utrecht
Mathews, Carol A.
United States, San Francisco
University of California, San Francisco
Statistics
Citations: 18
Authors: 12
Affiliations: 10
Identifiers
Doi:
10.1016/j.comppsych.2010.06.007
ISSN:
0010440X
Participants Gender
Male