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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Protective effects of selenium on methimazole nephrotoxicity in adult rats and their offspring
Experimental and Toxicologic Pathology, Volume 63, No. 6, Year 2011
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Description
This study aims to investigate the improving effects of selenium on methimazole-induced kidney impairments in adult rats and their pups. The animals were randomly divided into four groups of six each: group I served as control which received standard diet; group II received only methimazole in drinking water as 250mg/l; group III received both methimazole (250mg/l, orally) and selenium (0.5mg/kg of diet); group IV served as a positive control and received selenium (0.5mg/kg of diet) as sodium selenite (Na 2SeO 3). Treatments were started from the 14th day of pregnancy until day 14 after delivery. In the methimazole-treated group, body and absolute kidney weights decreased in pups and their mothers when compared to control. Daily urine volume, plasma creatinine levels were higher, while urinary levels were lower than in control. Besides, antioxidant enzyme activities, superoxide dismutase, catalase and glutathione peroxidase decreased. Lipid peroxidation recorded an increase revealed by high kidney malondialdehyde levels, while those of plasma and urinary uric acid showed a significant decline. Methimazole-treated rat kidneys exhibited leucocytic infiltrations, vascular congestion and narrowed Bowman's space. Co-administration of selenium through diet improved all the parameters cited above in adult rats and their progeny. Nevertheless, the distorted histoarchitecture in rat kidney was alleviated by selenium treatment. It can then be concluded that selenium is an important protective element that may be used as a dietary supplement against kidney impairments. © 2010 Elsevier GmbH.
Authors & Co-Authors
Ben Amara, Ibtissem
Tunisia, Sfax
University of Sfax
Troudi, Afef
Tunisia, Sfax
University of Sfax
Garoui, El Mouldi
Tunisia, Sfax
University of Sfax
Hakim, Ahmed
Tunisia, Sfa
Faculty of Medicine
Boudawara, Tahia Sellami
Tunisia, Sfax
Chu Habib Bourguiba
Zeghal, Khaled Mounir
Tunisia, Sfa
Faculty of Medicine
Zeghal, Najiba
Tunisia, Sfax
University of Sfax
Statistics
Citations: 31
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.etp.2010.04.007
ISSN:
09402993
e-ISSN:
16181433
Research Areas
Environmental
Maternal And Child Health
Sexual And Reproductive Health