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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Prevalence of hepatitis B and hepatitis C coinfections in an adult HIV centre population in Gaborone, Botswana
American Journal of Tropical Medicine and Hygiene, Volume 85, No. 2, Year 2011
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Description
The objective of this study was to assess the prevalence of hepatitis B and hepatitis C coinfections in human immunodeficiency virus (HIV) -infected adults at an HIV center in Gaborone, Botswana. A retrospective review was performed of charts of currently active HIV-infected adult patients in the Family Model Clinic (FMC) of the Botswana-Baylor Children's Clinical Center of Excellence (BCOE) in Gaborone, Botswana, for the results of serum hepatitis B surface antigen (HBsAg) and antihepatitis C IgG tests performed between January 1, 2005 and December 15, 2009. Of 308 active FMC patients, 266 underwent HBsAg serology testing within the period of study. The HBsAg coinfection prevalence was 5.3% (14/266); 2 of 252 patients had at least one positive antihepatitis C IgG serology, a 0.8% prevalence. Hepatitis B coinfection is relatively common in HIV-infected adults at our center in Botswana, whereas hepatitis C coinfection is rare. In this setting, where the diagnosis of hepatitis B coinfection with HIV has implications for choice of firstline antiretroviral therapy and prevention of perinatal hepatitis B transmission, broader sampling to establish the true population prevalence of hepatitis B coinfection and the desirability of adding screening to HIV management should be considered. These findings provide little justification for adding hepatitis C coinfection screening to the management of HIV infection in Botswana. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Patel, Premal G.
Botswana, Gaborone
Botswana Baylor Children's Clinical Center of Excellence
Davis, Stephanie Marie
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Tolle, Michael A.
Botswana, Gaborone
Botswana Baylor Children's Clinical Center of Excellence
Mabikwa, Vincent
Botswana, Gaborone
Botswana Baylor Children's Clinical Center of Excellence
Anabwani, Gabriel Misango
Botswana, Gaborone
Botswana Baylor Children's Clinical Center of Excellence
Statistics
Citations: 45
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.4269/ajtmh.2011.10-0510
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Botswana