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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Nigrosphaerin A a new isochromene derivative from the endophytic fungus Nigrospora sphaerica
Phytochemistry Letters, Volume 7, No. 1, Year 2014
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Description
Nigrosphaerin A, a new isochromene derivative (1), was isolated from the endophytic fungus Nigrospora sphaerica and chemically identified as 3-(3,4-dihydroxyphenyl)-4,6,8-trihydroxy-1H-isochromen-1-one-6-O-β-d- glucopyranoside. In addition nineteen known compounds (2-20) were isolated from the same fungus and chemically identified. Compounds (1-3, 5, and 7-16) were isolated for the first time from this fungus. In vitro antileukemic, antileishmanial, antifungal, antibacterial and antimalarial activities of (1-20) were examined. Compounds 5, 7, 9 and 10 showed good antileukemic activity against HL60 cells with IC50 values of 0.03, 0.39, 0.2 and 0.4 μg/mL, respectively and against K562 cells with IC50 values of 0.35, 0.35, 0.49 and 0.01 μg/mL, respectively. Compounds 3, 4 and 6 showed moderate antileishmanial activity with IC50 values of 30.2, 26.4 and 36.4 μg/ml, respectively. Compound 7 showed moderate antifungal activity against Cryptococcus neoformans with IC50 value of 14.8 μg/mL. © 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Authors & Co-Authors
Metwaly, Ahmed M.
United States, University
University of Mississippi School of Pharmacy
Egypt, Cairo
Faculty of Pharmacy
Kadry, Hazem A.
Egypt, Cairo
Faculty of Pharmacy
El-Hela, Atef Ahmed
Egypt, Cairo
Faculty of Pharmacy
Mohammed, Abd El Salam I.
Egypt, Cairo
Faculty of Pharmacy
Ma, Guoyi
United States, University
University of Mississippi School of Pharmacy
Cutler, Stephen J.
United States, University
University of Mississippi
Ross, Samir Anis
United States, University
University of Mississippi School of Pharmacy
United States, University
University of Mississippi
Statistics
Citations: 67
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.phytol.2013.09.001
e-ISSN:
18767486