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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Predictive performance of eGFR equations in South Africans of African and Indian ancestry compared with
99m
Tc-DTPA imaging
International Urology and Nephrology, Volume 44, No. 3, Year 2012
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Description
Background South African guidelines for early detection and management of chronic kidney disease (CKD) recommend using the Cockcroft-Gault (CG) or Modification of Diet in Renal Disease (MDRD) equations for calculating estimated glomerular filtration rate (eGFR) with the correction factor, 1.212, included for MDRD-eGFR in black patients. We compared eGFR against technetium-99m- diethylenetriaminepentaacetic acid ( 99mTc-DTPA) imaging. Methods Using clinical records, we retrospectively recorded demographic, clinical, and laboratory data as well as 99mTc-DTPA-measured GFR (mGFR) results obtained from routine visits. Data from 148 patients of African (n = 91) and Indian (n = 57) ancestry were analyzed. Results Median (IQR) mGFR was 38.5 (44) ml/ min/1.73 m 2, with no statistical difference between African and Indian patients (P = 0. 573). In African patients with stage 3 CKD, MDRD-eGFR (unadjusted for black ethnicity) overestimated mGFR by 5.3% [2.0 (16.0) ml/min/1.73 m 2] compared to CGeGFR and MDRD-eGFR (corrected for black ethnicity) that overestimated mGFR by 17.7% [6.0 (15.0) ml/min/1.73 m 2] and 17.1% [6.0 (17.5) ml/min/ 1.73 m 2], respectively. In stage 1-2, CKD eGFR overestimated mGFR by 52.5, 38.0, and 19.3% for CG, MDRD (ethnicity-corrected), and MDRD (without correction), respectively. In Indian stage 3 CKD patients, MDRD-eGFR underestimated mGFR by 35.6% [-21.0 (6.5) ml/min/1.73 m 2] and CG-eGFR by 4.4% [-2.0 (27.0) ml/min/1.73 m 2], while in stage 1-2 CKD, CG-eGFR and MDRD-eGFR overestimated mGFR by 13.8 and 6.3%, respectively. Conclusion MDRD-eGFR calculated without the African-American correction factor improved GFR prediction in African CKD patients and using the MDRD correction factor of 1.0 in Indian patients as in Caucasians may be inappropriate. © Springer Science+Business Media, B.V. 2011.
Authors & Co-Authors
Madala, Nomandla Daphne
South Africa, Durban
University of Kwazulu-natal
South Africa, Durban
The Nelson R. Mandela Medical School
Nkwanyana, Ntombifikile Maureen
South Africa, Durban
College of Health Sciences
Dubula, Thozama
South Africa, Durban
University of Kwazulu-natal
Naiker, Indiran P.
South Africa, Durban
University of Kwazulu-natal
Statistics
Citations: 40
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1007/s11255-011-9928-7
ISSN:
03011623
e-ISSN:
15732584
Research Areas
Noncommunicable Diseases