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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of bovine colostrum-based food supplement in the treatment of HIV-associated diarrhea in Northern Uganda: A randomized controlled trial
Indian Journal of Gastroenterology, Volume 30, No. 6, Year 2011
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Description
Aim HIV-associated diarrhea is common in HIV/AIDS patients in developing countries. An earlier uncontrolled study showed that a nutritional product made from bovine colostrum (ColoPlus®) alleviates HIV-associated diarrhea. We performed a randomized single-blind controlled trial of addition of colostrum-based supplement (ColoPlus®) to standard anti-diarrhea treatment in HIV/AIDS patients with diarrhea. Methods: Eighty-seven adult patients with HIV-associated diarrhea were recruited at Gulu Hospital and four community clinics in Northern Uganda. Forty-five patients were randomized to receive 50 g of colostrum-based supplement twice a day for 4 weeks in addition to standard anti-diarrhea treatment, and 42 patients received standard anti-diarrhea treatment alone. Patients were followed up for 9 weeks. Daily stool frequency was recorded, and body weight and body mass index were evaluated at weeks 1, 4 and 9. Baseline CD4+ count was measured at baseline and at week 9. Results: Mean daily stool frequency decreased by 79% from 7.5 to 1.3 motions over the study period in patients on colostrum-based supplement, compared to a 58% reduction in controls (p < 0.001). Self-reported fatigue was reduced by 85% in patients on colostrum-based supplement by week 9 compared to 43% reduction amongst controls (p < 0. 001). Patients on colostrum-based supplement had 11% increase (p < 0,001) in mean body weight and body mass index by week 9, but no changes were observed in control subjects. Mean CD4+ count increased by 14% for patients on colostrum-based supplement, in contrast to 12% decrease in controls (p < 0.001). Conclusions: This study shows that addition of colostrum-based supplement to standard therapy is effective in treatment of HIV-associated diarrhea. © 2011 Indian Society of Gastroenterology.
Authors & Co-Authors
Kaducu, Felix Ocaka
Uganda, Gulu
Gulu University
Okia, S. A.
Unknown Affiliation
Upenytho, George D.
Uganda, Gulu
Gulu Regional Referral Hospital
Elfstrand, Lidia
Sweden, Lund
Skånes Universitetssjukhus
Florén, Claes Henrik
Sweden, Lund
Skånes Universitetssjukhus
Statistics
Citations: 28
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1007/s12664-011-0146-0
e-ISSN:
09750711
Research Areas
Disability
Food Security
Health System And Policy
Infectious Diseases
Study Approach
Quantitative
Study Locations
Uganda