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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Evaluation of a PfHRP
2
and a pLDH-based rapid diagnostic test for the diagnosis of severe malaria in 2 populations of african children
Clinical Infectious Diseases, Volume 52, No. 9, Year 2011
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Description
Background. Rapid diagnostic tests (RDTs) now play an important role in the diagnosis of falciparum malaria in many countries where the disease is endemic. Although these tests have been extensively evaluated in uncomplicated falciparum malaria, reliable data on their performance for diagnosing potentially lethal severe malaria is lacking. Methods. We compared a Plasmodium falciparum histidine-rich-protein2 (PfHRP2)-based RDT and a Plasmodium lactate dehydrogenase (pLDH)-based RDT with routine microscopy of a peripheral blood slide and expert microscopy as a reference standard for the diagnosis of severe malaria in 1898 children who presented with severe febrile illness at 2 centers in Mozambique and Tanzania. Results. The overall sensitivity, specificity, positive predictive value, and negative predictive values of the PfHRP2-based test were 94.0%, 70.9%, 85.4%, and 86.8%, respectively, and for the pLDH-based test, the values were 88.0%, 88.3%, 93.2%, and 80.3%, respectively. At parasite counts <1000 parasites/μL (n = 173), sensitivity of the pLDH-based test was low (45.7%), compared with that of the PfHRP2-based test (69.9%). Both RDTs performed better than did the routine slide reading in a clinical laboratory as assessed in 1 of the centers. Conclusion. The evaluated PfHRP2-based RDT is an acceptable alternative to routine microscopy for diagnosing severe malaria in African children and performed better than did the evaluated pLDH-based RDT. © 2011 The Author.
Authors & Co-Authors
Hendriksen, Ilse C.E.
Unknown Affiliation
Mtove, George A.
Unknown Affiliation
Pedro, Alínia José
Unknown Affiliation
Gomes, Ermelinda
Unknown Affiliation
Silamut, Kamolrat
Unknown Affiliation
Lee, Sue J.
Unknown Affiliation
Mwambuli, Abraham
Unknown Affiliation
Gesase, Samwel
Unknown Affiliation
Reyburn, Hugh G.
Unknown Affiliation
Day, Nichloas P.J.
Unknown Affiliation
White, Nicholas J.
Unknown Affiliation
Von-Seidlein, Lorenz
Unknown Affiliation
Dondorp, A. M.
Unknown Affiliation
Statistics
Citations: 62
Authors: 13
Affiliations: 8
Identifiers
Doi:
10.1093/cid/cir143
ISSN:
10584838
e-ISSN:
15376591
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Mozambique
Tanzania