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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Common Variation Neighbouring Micro-RNA 22 Is Associated with Increased Left Ventricular Mass
PLoS ONE, Volume 8, No. 1, Article e55061, Year 2013
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Description
Aims: Previous genome-wide linkage analysis has suggested that chromosomal region 17p13.3 may harbour genes influencing left ventricular mass (LVM) in man. To date, the genetic factors accounting for LVM variability remain largely unknown but a non-coding RNA gene within this region, micro-RNA 22 (miR-22), has been implicated in cardiac hypertrophy and heart failure in animal models. We thus investigated the relationship between common genetic polymorphisms surrounding miR-22 and left ventricular mass in a family-based association study. Methods and Results: We studied a cohort of 255 families comprising 1,425 individuals ascertained via a hypertensive proband. Ten single nucleotide polymorphisms which together tagged common genetic variation surrounding the miR-22 gene were genotyped. There was evidence of association between the rs7223247 polymorphism, which lies within the 3′UTR of a gene of unknown function, TLCD2, immediately downstream from miR-22, and left ventricular mass determined by Sokolow-Lyon voltage (Bonferroni corrected p-value = 0.038). The T allele at rs7223247 was associated with an 0.272 standard deviation higher Sokolow-Lyon voltage. Genotype was responsible for ~1% of the population variability in LVM. Conclusions: Genotype at the rs7223247 polymorphism affects left ventricular mass determined by Sokolow-Lyon voltage. The neighbouring genes miR-22 and TLCD2 are strong candidates to account for this observation. © 2013 Harper et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3555935/bin/pone.0055061.s001.docx
Authors & Co-Authors
Harper, Andrew R.
United Kingdom, Newcastle
University of Newcastle Upon Tyne, Faculty of Medical Sciences
Mayosi, Bongani M.
South Africa, Observatory
Groote Schuur Hospital
Rodriguez, Antony
United States, Houston
Baylor College of Medicine
Rahman, Thahira J.
United Kingdom, Newcastle
University of Newcastle Upon Tyne, Faculty of Medical Sciences
Hall, Darroch H.
United Kingdom, Newcastle
University of Newcastle Upon Tyne, Faculty of Medical Sciences
Mamasoula, Chrysovalanto
United Kingdom, Newcastle
University of Newcastle Upon Tyne, Faculty of Medical Sciences
Avery, Peter J.
United Kingdom, Newcastle
Newcastle University
Keavney, Bernard D.
United Kingdom, Newcastle
University of Newcastle Upon Tyne, Faculty of Medical Sciences
Statistics
Citations: 8
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0055061
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study