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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Establishment of a lymphoid cell line from leukemic cells of a patient with chronic lymphocytic leukemia
International Journal of Cancer, Volume 26, No. 5, Year 1980
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Description
Two lymphoid cell lines were established from a patient with chronic lymphocytic leukemia by infecting blood cells with Epstein‐Barr virus (EBV). Studies of morphology, glucose‐6‐phosphate dehydrogenase, malic enzyme, immunoglobulin, and chromosomes of the two lines indicated that one of them originated from leukemic cells while the other arose from residual normal blood cells. The morphology and capacity for immunoglobulin secretion in the line that arose from leukemic cells were similar to those found in EVB‐carrying lymphoblastoid cell lines grown from patients without neoplasia and differed from those seen in fresh chronic lymphocytic leukemia cells. These observations suggest that the introduction of EBV into the leukemic cells may have caused them to differentiate in a fashion similar to that noted in normal B cells after exposure to EBV. Copyright © 1980 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Karande, A.
Sweden, Stockholm
Karolinska Institutet
Fialkow, Phillip J.
United States
Va Medical Center
United States, Seattle
University of Washington
Nilsson, K.
Sweden, Uppsala
Uppsala Universitet
Povey, Susanne M.
United Kingdom, London
University College London
Klein, George O.
Sweden, Stockholm
Karolinska Institutet
Najfeld, Vesna
United States
Va Medical Center
United States, Seattle
University of Washington
Penfold, Grace K.
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 39
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1002/ijc.2910260505
ISSN:
00207136
e-ISSN:
10970215
Research Areas
Health System And Policy