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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Executive summary of the Stages of Reproductive Aging Workshop + 10: Addressing the unfinished agenda of staging reproductive aging
Fertility and Sterility, Volume 97, No. 4, Year 2012
Notification
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Description
Objective: The aim of this article is to summarize the recommended updates to the 2001 Stages of Reproductive Aging Workshop (STRAW) criteria. The 2011 STRAW + 10 reviewed advances in understanding of the critical changes in hypothalamic-pituitary-ovarian function that occur before and after the final menstrual period. Method(s): Scientists from five countries and multiple disciplines evaluated data from cohort studies of midlife women and in the context of chronic illness and endocrine disorders on change in menstrual, endocrine, and ovarian markers of reproductive aging including antimüllerian hormone, inhibin-B, follicle-stimulating hormone, and antral follicle count. Modifications were adopted by consensus. Result(s): STRAW + 10 simplified bleeding criteria for the early and late menopausal transition, recommended modifications to criteria for the late reproductive stage (Stage -3) and the early postmenopause stage (Stage +1), provided information on the duration of the late transition (Stage -1) and early postmenopause (Stage +1), and recommended application regardless of women's age, ethnicity, body size, or lifestyle characteristics. Conclusion(s): STRAW + 10 provides a more comprehensive basis for assessing reproductive aging in research and clinical contexts. Application of the STRAW + 10 staging system should improve comparability of studies of midlife women and facilitate clinical decision making. Nonetheless, important knowledge gaps persist, and seven research priorities are identified. © 2012 by American Society for Reproductive Medicine.
Authors & Co-Authors
Harlow, Siobán D.
United States, Ann Arbor
University of Michigan, Ann Arbor
Gass, Margery L.S.
United States, Mayfield Heights
North American Menopause Society
Hall, Janet E.
United States, Boston
Harvard Medical School
Lobo, Roger
United States, New York
Columbia University
Maki, P. M.
United States, Chicago
University of Illinois at Chicago
Rebar, Robert William
United States, Washington, D.c.
American Society for Reproductive Medicine
Sherman, Sherry
United States, Bethesda
National Institute of Aging
Sluss, Patrick M.
United States, Boston
Harvard Medical School
de Villiers, Tobias J.
South Africa, Cape Town
International Menopause Society
Statistics
Citations: 296
Authors: 9
Affiliations: 8
Identifiers
Doi:
10.1016/j.fertnstert.2012.01.128
ISSN:
00150282
e-ISSN:
15565653
Research Areas
Health System And Policy
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Female