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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite
Nature, Volume 335, No. 6185, Year 1988
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Description
As a consequence of gene cloning and DNA sequencing several gene families are emerging in the field of cell-cell recognition. These include immunoglobulins, integrins, certain extracellular glycoproteins1 and a family of functionally unrelated proteins which include factor B2. We report here the cloning and sequencing of a gene from Plasmodium falciparum, coding for a protein we call thrombospondin related anonymous protein (TRAP), which shares certain sequence motifs common to other well-characterized proteins. The most significant homology is based around the sequence Trp-Ser-Pro-Cys-Ser-Val-Thr-Cys-Gly (WSPCSVTCG), present in three copies in region I of thrombospondin (TSP)3, six copies in properdin4 (P) and one copy in all the circumsporozoite (CS) proteins5-10 sequenced so far. TRAP also shares with certain extracellular glycoproteins, including TSP, the cell-recognition signal Arg-Gly-Asp (RGD)11, which has been shown to be crucial in the interaction of several extracellular glycoproteins with members of the integrin superfamily. Unlike the CS protein, TRAP is expressed during the erythrocytic stage of the parasite life cycle. © 1988 Nature Publishing Group.
Authors & Co-Authors
Robson, Kathryn J.H.
United Kingdom, Oxford
John Radcliffe Hospital
Marsh, Kevin
United Kingdom, Oxford
John Radcliffe Hospital
Newbold, Chris I.
United Kingdom, Oxford
John Radcliffe Hospital
Weatherall, David J.
United Kingdom, Oxford
John Radcliffe Hospital
Statistics
Citations: 344
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1038/335079a0
ISSN:
00280836
Research Areas
Genetics And Genomics
Infectious Diseases