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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression
AIDS, Volume 24, No. 6, Year 2010
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Description
Background: Both T-cell activation during early HIV-1 infection and soluble markers of immune activation during chronic infection are predictive of HIV disease progression. Although the acute phase of HIV infection is associated with increased pro-inflammatory cytokine production, the relationship between cytokine concentrations and HIV pathogenesis is unknown. Objectives: To identify cytokine biomarkers measurable in plasma during acute HIV-1 infection that predict HIV disease progression. Design: Study including 40 South African women who became infected with HIV-1 and were followed longitudinally from the time of infection. Methods: The concentrations of 30 cytokines in plasma from women with acute HIV-1 infection were measured and associations between cytokine levels and both viral load set point 12 months postinfection and time taken for CD4 cell counts to fall below 350 cells/μl were determined using multivariate and Cox proportional hazards regression. Results: We found that the concentrations of five plasma cytokines, IL-12p40, IL-12p70, IFN-γ, IL-7 and IL-15 in women with acute infection predicted 66% of the variation in viral load set point 12 months postinfection. IL-12p40, IL-12p70 and IFN-γ were significantly associated with lower viral load, whereas IL-7 and IL-15 were associated with higher viral load. Plasma concentrations of IL-12p40 and granulocyte-macrophage colony-stimulating factor during acute infection were associated with maintenance of CD4 cell counts above 350 cells/μl, whereas IL-1α, eotaxin and IL-7 were associated with more rapid CD4 loss. Conclusion: A small panel of plasma cytokines during acute HIV-1 infection was predictive of long-term HIV disease prognosis in this group of South African women. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Authors & Co-Authors
Masson, Lindi
South Africa, Cape Town
University of Cape Town
Passmore, Jo Ann Shelley
South Africa, Cape Town
University of Cape Town
South Africa, Johannesburg
National Health Laboratory Service
Williamson, Carolyn
South Africa, Cape Town
University of Cape Town
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Little, Francesca
South Africa, Cape Town
University of Cape Town
Bebell, Lisa M.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
United States, New York
Columbia University
Mlisana, Koleka P.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Burgers, Wendy A.
South Africa, Cape Town
University of Cape Town
van Loggerenberg, Francois
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Walzl, Gerhard
South Africa, Stellenbosch
Stellenbosch University
Djoba-Siaway, Joël Fleury
South Africa, Stellenbosch
Stellenbosch University
Abdool Karim, Quarraisha Abdool
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
United States, New York
Columbia University
Abdool Karim, Salim S.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
United States, New York
Columbia University
Statistics
Citations: 218
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1097/QAD.0b013e3283367836
e-ISSN:
14735571
Research Areas
Infectious Diseases
Participants Gender
Female