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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Effect of Orthostasis on Endothelial Function: A Gender Comparative Study
PLoS ONE, Volume 8, No. 8, Article e71655, Year 2013
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Description
As the vascular endothelium has multiple functions, including regulation of vascular tone, it may play a role in the pathophysiology of orthostatic intolerance. We investigated the effect of orthostasis on endothelial function using EndoPAT®, a non-invasive and user-independent method, and across gender. As sex steroid hormones are known to affect endothelial function, this study examined the potential effect of these hormones on the endothelial response to orthostasis by including females at different phases of the menstrual cycle (follicular and luteal-where the hormone balance differs), and females taking an oral contraceptive. A total of 31 subjects took part in this study (11 males, 11 females having normal menstrual cycles and 9 females taking oral contraceptive). Each subject made two visits for testing; in the case of females having normal menstrual cycles the first session was conducted either 1-7 (follicular) or 14-21 days (luteal) after the start of menstruation, and the second session two weeks later, i.e., during the other phase, respectively. Endothelial function was assessed at baseline and following a 20-min orthostatic challenge (active standing). The EndoPAT® index increased from 1.71 ± 0.09 (mean ± SEM) at baseline to 2.07 ± 0.09 following orthostasis in females (p<0.001). In males, the index increased from 1.60 ± 0.08 to 1.94 ± 0.13 following orthostasis (p<0.001). There were no significant differences, however, in the endothelial response to orthostasis between females and males, menstrual cycle phases and the usage of oral contraceptive. Our results suggest an increased vasodilatatory endothelial response following orthostasis in both females and males. The effect of gender and sex hormones on the endothelial response to orthostasis appears limited. Further studies are needed to determine the potential role of this post orthostasis endothelial response in the pathophysiology of orthostatic intolerance. © 2013 Goswami et al.
Authors & Co-Authors
Goswami, Nandu
Austria, Graz
Medizinische Universität Graz
Gorur, Paavan
United Kingdom, London
King's College London
Pilsl, Ulrike
Austria, Graz
Medizinische Universität Graz
Anyaehie, Ugochukwu Bond
Nigeria, Naukka
University of Nigeria
Green, David A.
United Kingdom, London
King's College London
Bondarenko, Alexander I.
Ukraine, Kyiv
Bogomoletz Institute of Physiology
Roessler, Andreas
Austria, Graz
Medizinische Universität Graz
Hinghofer-Szalkay, Helmut (cm3)
Austria, Graz
Medizinische Universität Graz
Statistics
Citations: 13
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0071655
e-ISSN:
19326203
Research Areas
Health System And Policy
Sexual And Reproductive Health
Participants Gender
Female