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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Outstanding effect of the conformational restriction of isoquinolines: Hints for the development of optimized antimicrobial agents
Research on Chemical Intermediates, Volume 39, No. 7, Year 2013
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Description
Conformational restriction constitutes a useful strategy of molecular modification for the design of new potential drug candidates. Herein we present the planning, antimicrobial evaluation, and establishment of structure-activity relationship (SAR) data for some isoxazole (3a-k, 8a-c, and 9a-c) and pyrazole (5a-h) derivatives. These derivatives were structurally designed by conformational restriction followed by bioisosteric exchange of previously described antimicrobial isoquinolines (1a-c). Some of these more conformationally restricted derivatives present improved properties as new antibacterial drug candidates. © 2012 Springer Science+Business Media B.V.
Authors & Co-Authors
Ozcelik, Berrin
Turkey, Ankara
Gazi Üniversitesi
Sheikh, Javed I.
India
Dhote Bandu Science College
Orhan, I. E.
Turkey, Famagusta
Eastern Mediterranean University
Juneja, Harjeet D.
India, Nagpur
Rashtrasant Tukadoji Maharaj Nagpur University
Bennani, Brahim
Morocco, Fez
Laboratoire de Chimie Organique, Université Sidi Mohamed Ben Abdellah
Kerbal, Abdelali
Morocco, Fez
Laboratoire de Chimie Organique, Université Sidi Mohamed Ben Abdellah
Cavalcanti, S. M.T.
Brazil, Recife
Center of Health Sciences
Leite, Ana C.L.
Brazil, Recife
Center of Health Sciences
Ben Hadda, Taibi
Morocco, Oujda
Université Mohammed Premier Oujda
Statistics
Citations: 9
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1007/s11164-012-0808-2
ISSN:
09226168
e-ISSN:
15685675