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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Fractionated neem leaf extract is safe and increases CD4
+
cell levels in HIV/AIDS patients
American Journal of Therapeutics, Volume 14, No. 4, Year 2007
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Description
The safety and effect of an acetone-water neem leaf extract (IRAB) on CD4 cells was investigated in 60 HIV/AIDS patients as part of an ongoing study to determine the influence of neem on immunity and viral load in HIV/AIDS. Patients were confirmed as HIV I or II positive, as having CD4 cell count, less than 300 cells/μL, and as antiretrovirally naïve. They were given oral IRAB (1.0 g daily for 12 weeks). Clinical and laboratory tests were carried out at baseline and at 4 weekly intervals. Thus, the patients served as their own controls. Sixty patients completed treatment. Fifty (83.33%) were completely compliant with respect to laboratory tests. Increase in mean CD4 cells, 266 cells/μL (159%), for the 50 patients was significant (P < 0.001) between baseline and week 12. Erythrocyte sedimentation rate (64 mm/hr at baseline) was 16 mm/hr at week 12, whereas total number of incidences of HIV/AIDS-related pathologies decreased from 120 at baseline to 5. Mean bodyweight, hemoglobin concentration, and lymphocyte differential count increased significantly by 12% (P < 0.05), 24% (P < 0.0001), and 20% (P < 0.0001), respectively. There were no adverse effects and no abnormalities in kidney and liver function parameters. The results support the safety of IRAB in HIV/AIDS, and its significant influence on CD4 cells may be useful in the formulation of multidrug combination therapies for HIV/AIDS. However, its antiretroviral activity is being evaluated in our laboratory. © 2007 Lippincott Williams & Wilkins, Inc.
Authors & Co-Authors
Mbah, A. U.
Nigeria, Naukka
University of Nigeria
Udeinya, Iroka J.
Nigeria, Enugu
Rocitus Institute of Research
Shu, Elvis Neba
Nigeria, Naukka
University of Nigeria
Chijioke, Chioli Pascal
Nigeria, Naukka
University of Nigeria
Nubila, T.
Nigeria, Naukka
University of Nigeria
Udeinya, F. I.
Nigeria, Enugu
Rocitus Institute of Research
Muobuike, Angela
Nigeria, Enugu
Annunciation Specialist Hospital
Mmuobieri, Ancila
Nigeria, Enugu
Annunciation Specialist Hospital
Obioma, Maria S.
Nigeria, Enugu
Mother of Christ Specialist Hospital
Statistics
Citations: 50
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1097/MJT.0b013e3180a72199
ISSN:
10752765
Research Areas
Environmental
Health System And Policy
Infectious Diseases