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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
IL-10-producing regulatory B cells in the pathogenesis of chronic hepatitis B virus infection
Journal of Immunology, Volume 189, No. 8, Year 2012
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Description
A regulatory subset of B cells has been found to modulate immune responses in autoimmunity, infection, and cancer, but it has not been investigated in the setting of human persistent viral infection. IL-10 is elevated in patients with chronic hepatitis B virus infection (CHB), but its cellular sources and impact on antiviral T cells have not been addressed. We investigated the role of IL-10 and regulatory B cells in the pathogenesis of CHB. Serum IL-10 levels were studied longitudinally in patients with CHB undergoing spontaneous disease flares. There was a close temporal correlation between IL-10 levels and fluctuations in viral load or liver inflammation. Blockade of IL-10 in vitro rescued polyfunctional virus-specific CD8 T cell responses. To investigate the potential contribution of regulatory B cells, their frequency was measured directly ex vivo and after exposure to stimuli relevant to hepatitis B virus (HBV) (CpG or HBV Ags). IL-10-producing B cells were enriched in patients, and their frequency correlated temporally with hepatic flares, both after stimulation and directly ex vivo. Phenotypically, these cells were predominantly immature (CD19+CD24hiCD38hi) ex vivo; sorted CD19+CD24hiCD38hi cells suppressed HBV-specific CD8 T cell responses in an IL-10-dependent manner. In summary, these data reveal a novel IL-10-producing subset of B cells able to regulate T cell immunity in CHB. Copyright © 2012 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Peppa, Dimitra
United Kingdom, London
University College London
Dusheiko, Geoffrey M.
United Kingdom, London
University College London
Gill, Upkar Singh
United Kingdom, London
Barts and the London School of Medicine and Dentistry
Kennedy, Patrick T.F.
United Kingdom, London
Barts and the London School of Medicine and Dentistry
Brunetto, M. R.
Italy, Pisa
Ospedale Santa Chiara Pisa
Lampertico, Pietro
Italy, Milan
Università Degli Studi Di Milano
Maini, Mala K.
United Kingdom, London
University College London
Statistics
Citations: 310
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.4049/jimmunol.1103139
ISSN:
15506606
Research Areas
Cancer
Infectious Diseases