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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Seroprevalence and distribution of arboviral infections among rural Kenyan adults: A cross-sectional study
Virology Journal, Volume 8, Article 371, Year 2011
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Description
Background: Arthorpod-borne viruses (arboviruses) cause wide-spread morbidity in sub-Saharan Africa, but little research has documented the burden and distribution of these pathogens. Methods. Using a population-based, cross-sectional study design, we administered a detailed questionnaire and used ELISA to test the blood of 1,141 healthy Kenyan adults from three districts for the presence of anti-viral Immunoglobulin G (IgG) antibodies to the following viruses: dengue (DENV), West Nile (WNV), yellow fever (YFV), Chikungunya (CHIKV), and Rift Valley fever (RVFV). Results: Of these, 14.4% were positive for DENV, 9.5% were WNV positive, 9.2% were YFV positive, 34.0% were positive for CHIKV and 0.7% were RVFV positive. In total, 46.6% had antibodies to at least one of these arboviruses. Conclusions: For all arboviruses, district of residence was strongly associated with seropositivity. Seroprevalence to YFV, DENV and WNV increased with age, while there was no correlation between age and seropositivity for CHIKV, suggesting that much of the seropositivity to CHIKV is due to sporadic epidemics. Paradoxically, literacy was associated with increased seropositivity of CHIKV and DENV. © 2011 Mease et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Mease, Luke E.
United States, Silver Spring
Walter Reed Army Institute of Research
United States, Bethesda
Uniformed Services University of the Health Sciences
Coldren, Rodney Leland
United States, Bethesda
Uniformed Services University of the Health Sciences
Musila, Lillian A.
Kenya, Nairobi
Kenya Medical Research Institute
Prosser, Trish
United States, Aberdeen Proving Ground
Health Promotion and Wellness
Ogolla, Fredrick
Kenya, Nairobi
Kenya Medical Research Institute
Ofula, Victor O.
Kenya, Nairobi
Kenya Medical Research Institute
Schoepp, Randal J.
United States, Fort Detrick
U.s. Army Medical Research Institute of Infectious Diseases
Rossi, Cynthia Ann
United States, Fort Detrick
U.s. Army Medical Research Institute of Infectious Diseases
Adungo, Nicholas I.
Kenya, Nairobi
Kenya Medical Research Institute
Statistics
Citations: 97
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1186/1743-422X-8-371
e-ISSN:
1743422X
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative