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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Differentiating the roles of STAT5B and STAT5A in human CD4
+
T cells
Clinical Immunology, Volume 148, No. 2, Year 2013
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Description
STAT5A and STAT5B are highly homologous proteins whose distinctive roles in human immunity remain unclear. However, STAT5A sufficiency cannot compensate for STAT5B defects, and human STAT5B deficiency, a rare autosomal recessive primary immunodeficiency, is characterized by chronic lung disease, growth failure and autoimmunity associated with regulatory T cell (Treg) reduction. We therefore hypothesized that STAT5A and STAT5B play unique roles in CD4+ T cells. Upon knocking down STAT5A or STAT5B in human primary T cells, we found differentially regulated expression of FOXP3 and IL-2R in STAT5B knockdown T cells and down-regulated Bcl-X only in STAT5A knockdown T cells. Functional ex vivo studies in homozygous STAT5B-deficient patients showed reduced FOXP3 expression with impaired regulatory function of STAT5B-null Treg cells, also of increased memory phenotype. These results indicate that STAT5B and STAT5A act partly as non-redundant transcription factors and that STAT5B is more critical for Treg maintenance and function in humans. © 2013 Elsevier Inc.
Authors & Co-Authors
Jenks, Jennifer A.
United States, Stanford
Stanford University School of Medicine
Seki, Scott
United States, Stanford
Stanford University School of Medicine
Kanai, Takahiro
United States, Stanford
Stanford University School of Medicine
Huang, Jennifer
United States, Stanford
Stanford University School of Medicine
Morgan, Alexander A.
United States, Palo Alto
Stanford University
Scalco, Renata C.
Brazil, Sao Paulo
Universidade de São Paulo
Nath, Ruhi
United States, Stanford
Stanford University School of Medicine
Bucayu, Robert
United States, Stanford
Stanford University School of Medicine
Wit, J. M.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Al-Herz, Waleed
Kuwait
Al-sabah Hospital
Kuwait, Kuwait City
Kuwait University
Ramadan, D. G.
Kuwait
Al-sabah Hospital
Jorge, Alexander A.
Brazil, Sao Paulo
Universidade de São Paulo
Bacchetta, Rosa
United States, Stanford
Stanford University School of Medicine
Italy, Milan
San Raffaele Telethon Institute for Gene Therapy
Hwa, Vivian
United States, Portland
Doernbecher Children's Hospital
Rosenfeld, Ron G.
United States, Portland
Doernbecher Children's Hospital
Nadeau, Kari Christine
United States, Stanford
Stanford University School of Medicine
Statistics
Citations: 45
Authors: 16
Affiliations: 8
Identifiers
Doi:
10.1016/j.clim.2013.04.014
ISSN:
15216616
e-ISSN:
15217035