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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Comparative genomics of the mimicry switch in Papilio dardanus
Proceedings of the Royal Society B: Biological Sciences, Volume 281, No. 1787, Article 20140465, Year 2014
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Description
The African Mocker Swallowtail, Papilio dardanus, is a textbook example in evolutionary genetics. Classical breeding experiments have shown that wing pattern variation in this polymorphic Batesian mimic is determined by the polyallelic H locus that controls a set of distinct mimetic phenotypes. Using bacterial artificial chromosome (BAC) sequencing, recombination analyses and comparative genomics,we showthatHco-segregateswith an interval of less than 500 kb that is collinear with two other Lepidoptera genomes and contains 24 genes, including the transcription factor genes engrailed (en) and invected (inv). H is located in a region of conserved gene order, which argues against any role for genomic translocations in the evolution of a hypothesizedmulti-gene mimicry locus. Natural populations of P. dardanus show significant associations of specific morphs with single nucleotide polymorphisms (SNPs), centred on en. In addition, SNP variation in the H region reveals evidence of non-neutral molecular evolution in the en gene alone. We find evidence for a duplication potentially driving physical constraints on recombination in the lamborni morph. Absence of perfect linkage disequilibrium between different genes in the other morphs suggests that H is limited to nucleotide positions in the regulatory and coding regions of en. Our results therefore support the hypothesis that a single gene underlies wing pattern variation in P. dardanus. © 2014 The Authors Published by the Royal Society. All rights reserved.
Authors & Co-Authors
Timmermans, Martijn J.T.N.
United Kingdom, London
The Natural History Museum, London
United Kingdom, London
Imperial College London
Baxter, Simon W.
United Kingdom, Cambridge
University of Cambridge
Clark, Rebecca I.
United Kingdom, London
The Natural History Museum, London
United Kingdom, London
Imperial College London
Heckel, David G.
Germany, Jena
Max Planck Institute for Chemical Ecology
Vogel, Heiko
Germany, Jena
Max Planck Institute for Chemical Ecology
Collins, Steve C.
Kenya, Nairobi
African Butterfly Research Institute, Nairobi
Papanicolaou, Alexie
United Kingdom, Exeter
University of Exeter
Australia, Black Mountain
Csiro Ecosystem Sciences
Fuková, Iva
United Kingdom, Exeter
University of Exeter
Joron, Mathieu
France, Paris
Museum National D'histoire Naturelle
Thompson, Martin J.
United Kingdom, London
The Natural History Museum, London
United Kingdom, Cambridge
University of Cambridge
Jiggins, Chris D.
United Kingdom, Cambridge
University of Cambridge
Ffrench-Constant, Richard H.
United Kingdom, Exeter
University of Exeter
Vogler, Alfried P.
United Kingdom, London
The Natural History Museum, London
United Kingdom, London
Imperial College London
Statistics
Citations: 47
Authors: 13
Affiliations: 8
Identifiers
Doi:
10.1098/rspb.2014.0465
ISSN:
09628452
e-ISSN:
14712954
Research Areas
Cancer
Genetics And Genomics