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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Statins and inflammation: New therapeutic opportunities in psychiatry
Frontiers in Psychiatry, Volume 10, No. MAR, Article 103, Year 2019
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Description
Statins, which are widely used to treat hypercholesterolemia, have anti-inflammatory and anti-oxidant effects. These are thought to be responsible for the potential effects of statins on various psychiatric disorders. In this study, we comprehensively review the literature to investigate the effects of statins on various psychiatric disorders including depression, schizophrenia, and dementia. In addition, we review adverse effects and drug interactions of statins to give clinically useful information guiding statin use in the psychiatric field. Statins seem useful in reducing depression, particularly in patients with physical disorders such as cardiovascular disease. In patients with schizophrenia, negative symptoms may be reduced by adjuvant statin therapy. Studies on cohorts at risk for dementia have generally shown protective effects of statins, while those on treatment for dementia show inconsistent results. In conclusion, statins used in combination with conventional psychotropic medications may be effective for various psychiatric disorders including depression, schizophrenia, and dementia. Further study is required to determine optimal doses and duration of statin use for the treatment of psychiatric disorders. Copyright © 2019 Kim, Kang, Jhon, Kim, Lee, Walker, Agustini, Kim and Berk.
Authors & Co-Authors
Berk, Michael
Australia, Geelong
Deakin University
Australia, Melbourne
University of Melbourne
Australia, Melbourne
The Florey
Australia, Melbourne
Orygen Youth Health
Statistics
Citations: 78
Authors: 1
Affiliations: 5
Identifiers
Doi:
10.3389/fpsyt.2019.00103
ISSN:
16640640
Research Areas
Mental Health
Noncommunicable Diseases
Study Design
Cohort Study