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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The induction of inflammation by dectin-1 in vivo is dependent on myeloid cell programming and the progression of phagocytosis
Journal of Immunology, Volume 181, No. 5, Year 2008
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Description
Dectin-1 is the archetypal signaling, non-Toll-like pattern recognition receptor that plays a protective role in immune defense to Candida albicans as the major leukocyte receptor for β-glucans. Dectin-1-deficiency is associated with impaired recruitment of inflammatory leukocytes and inflammatory mediator production at the site of infection. In this study, we have used mice to define the mechanisms that regulate the dectin-1-mediated inflammatory responses. Myeloid cell activation by dectin-1 is controlled by inherent cellular programming, with distinct macrophage and dendritic cell populations responding differentially to the engagement of this receptor. The inflammatory response is further modulated by the progression of the phagocytosis, with "frustrated phagocytosis" resulting in dramatically augmented inflammatory responses. These studies demonstrate that dectin-1 in isolation is sufficient to drive a potent inflammatory response in a context-dependent manner. This has implications for the mechanism by which myeloid cells are activated during fungal infections and the processes involved in the therapeutic manipulation of the immune system via exogenous dectin-1 stimulation or blockade. Copyright © 2008 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Rosas, Marcela
United Kingdom, Cardiff
Cardiff University School of Medicine
Liddiard, Kate
United Kingdom, Cardiff
Cardiff University School of Medicine
Kimberg, Matti
South Africa, Cape Town
University of Cape Town
Faro-Trindade, Inês
South Africa, Cape Town
University of Cape Town
McDonald, Jacqueline U.
United Kingdom, Cardiff
Cardiff University School of Medicine
Williams, David L.
United States, Johnson
Quillen-dishner College of Medicine
Brown, Gordon D.A.
South Africa, Cape Town
University of Cape Town
Taylor, Philip Russel
United Kingdom, Cardiff
Cardiff University School of Medicine
Statistics
Citations: 133
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.4049/jimmunol.181.5.3549
ISSN:
00221767
e-ISSN:
15506606