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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Differentiation of monocytes into CD1a- dendritic cells correlates with disease progression in HIV-infected patients
Journal of Acquired Immune Deficiency Syndromes, Volume 46, No. 5, Year 2007
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Description
Monocyte differentiation into dendritic cells (DCs) depends on microenvironmental conditions. In this study, the capacity of human monocytes to differentiate into mature DCs and their ability to induce an antiviral immune response was investigated in HIV-infected patients. In healthy subjects, monocytes differentiate into CD1a DCs in the presence of granulocyte macrophage colony-stimulating factor and interleukin (IL)-4 and matured in the presence of lipopolysaccharide. Here, we found that in 30% and 45% of HIV-infected white and African subjects, respectively, monocytes gave rise to a homogeneous CD1a DC population. In the patients who gave rise only to the CD1a DCs, this population spontaneously produced IL-10 but not IL-12, and induced a T helper 2-like immune response when cultured with human T cells isolated from cord blood mononuclear cells. In patients with monocytes differentiated into CD1a DCs, a high percentage of HIV-specific CD4 T cells producing IL-4 were seen in the peripheral blood. Furthermore, differentiation of monocytes into DCs with CD1a phenotype correlated with low CD4 T-cell counts and high viral loads in HIV-infected subjects. These results suggest that the differentiation of monocytes into CD1a DCs may be a phenotypic marker associated with progression of the disease. © 2007 Lippincott Williams & Wilkins, Inc.
Authors & Co-Authors
Sacchi, Alessandra
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Cappelli, Giulia
Italy, Rome
Consiglio Nazionale Delle Ricerche
Cairo, Cristiana
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Martino, Angelo
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Sanarico, Nunzia
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
D'Offizi, Gianpiero
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Pupillo, Leopoldo Paolo
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Chenal, Henri
Cote D'ivoire, Abidjan
Centre Intégré de Recherches Biocliniques D'abidjan Cirba
de Libero, Gennaro
Switzerland, Basel
Universitätsspital Basel
Colizzi, Vittorio C.
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Vendetti, Silvia
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Italy, Rome
Istituto Superiore Di Sanita
Statistics
Citations: 13
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1097/QAI.0b013e31815b1278
ISSN:
15254135
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study